{"id":21714,"date":"2024-01-29T13:52:17","date_gmt":"2024-01-29T11:52:17","guid":{"rendered":"https:\/\/umfst.ro\/?page_id=21714"},"modified":"2026-04-16T12:33:11","modified_gmt":"2026-04-16T09:33:11","slug":"biomarkers_alzheimer-s_disease","status":"publish","type":"page","link":"https:\/\/umfst.ro\/en\/universitate\/departament-proiecte-europene\/anunturi\/pnrr\/biomarkers_alzheimer-s_disease\/","title":{"rendered":"Intramural cells as biomarkers and therapeutic targets for Alzheimer’s disease"},"content":{"rendered":"
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Proiect<\/strong><\/p>\n<\/td>\n

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Intramural cells as biomarkers and therapeutic targets for Alzheimer’s disease\u201d <\/strong> .<\/p>\n

Finan\u021bat \u00een cadrul Planului Na\u021bional de Redresare \u0219i Rezilien\u021b\u0103 a Rom\u00e2niei (PNRR) Apel nr.PNRR-III-C9-2022-I8 <\/strong><\/p>\n

Pilon III<\/strong>:<\/strong> Cre\u0219tere inteligent\u0103, durabil\u0103 \u0219i favorabil\u0103 incluziunii, inclusiv coeziune economic\u0103, locuri de munc\u0103, productivitate, competitivitate, cercetare, dezvoltare \u0219i inovare \u0219i o pia\u021b\u0103 intern\u0103 care func\u021bioneaz\u0103 bine, cu \u00eentreprinderi mici \u0219i mijlocii (IMM-uri) puternice <\/strong><\/p>\n

Componenta 9<\/strong> : Suport pentru sectorul privat, cercetare, dezvoltare \u0219i inovare<\/p>\n

Investitia 8<\/strong> : Dezvoltarea unui program pentru atragerea resurselor umane \u00eenalt specializate din str\u0103in\u0103tate \u00een activit\u0103\u021bi de cercetare \u0219i inovare<\/p>\n<\/td>\n<\/tr>\n

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Contract de finan\u021bare<\/p>\n<\/td>\n

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Nr.760108\/23.05.2023 ;\u00a0 CF 63\/14.11.2022<\/p>\n<\/td>\n<\/tr>\n

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Beneficiar<\/p>\n<\/td>\n

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George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures<\/p>\n<\/td>\n<\/tr>\n

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Descrierea Proiectului<\/p>\n<\/td>\n

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Boala Alzheimer (BA) este cea mai comun\u0103 form\u0103 de demen\u021b\u0103, care afecteaz\u0103 8 milioane de europeni. O caracteristic\u0103 cheie a BA este acumularea de peptide beta-amiloid \u00een capilarele \u0219i arterele cerebrale determin\u00e2nd angiopatia amiloid\u0103 cerebral\u0103 (AAC), ce apare ca un e\u0219ec al clearance-ului de-a lungul c\u0103ilor de drenaj periarterial intramural (DPAM) \u0219i care este asociat\u0103. cu o sc\u0103dere a func\u021biei celulelor murale \u0219i a vasomotricit\u0103\u021bii. Scopul este \u00een primul r\u00e2nd de dezvoltare a rolurilor \u0219i modific\u0103rile celulelor murale cerebrovasculare \u00een patogeneza AAC\/BA, utilizat noi modele in vivo<\/em>, \u021besut uman post-mortem, microdisec\u021bie cu laser ex vivo <\/em> \u0219i sisteme microfluidice de culturi celulare. \u00cen al doilea r\u00e2nd, vom folosi o nou\u0103 abla\u021bie electrochimic\u0103 in vivo <\/em> \u0219i interven\u021bii terapeutice pentru a restabili un DPAM normal \u00een modele cu celule murale vasculare absente. \u00cen al treilea r\u00e2nd, vom implementa noi biomarkeri imagistici \u0219i serologici ai celulelor murale cerebrovasculare umane normale. Vor fi testate urm\u0103toarele ipoteze: 1) pericitele \u0219i celulele musculare netede vasculare sunt direct implicate \u00een DPAM; 2) celulele murale cerebrovasculare sufer\u0103 modific\u0103ri morfologice \u0219i moleculare specifice \u00een creierul uman \u00eemb\u0103tr\u00e2nit; 3) receptorii adrenergici colinergici ai celulelor musculare netede vasculare sunt integri \u00een \u00eemb\u0103tr\u00e2nire \u0219i BA; 4) DPAM e\u0219ueaz\u0103 dup\u0103 abla\u021bia Locus Coeruleus<\/em>and Nucleus Basalis Meynert <\/em> \u0219i este restabilit la valori normale dup\u0103 adrenergici \u0219i colinergici; 5) func\u021bia celulelor murale cerebrovasculare poate fi detectat\u0103 prin investiga\u021bii imagistice ale creierului uman \u0219i biomarkeri ai lichidului cefalorahidian. Acest proiect promite s\u0103 clarifice mecanismul exact prin care celulele murale sunt elemente cheie pentru DPAM, s\u0103 identifice nu \u021binte terapeutice sub form\u0103 de ajutor adrenergici \u0219i colinergici, \u0219i noi biomarkeri imagistici \u0219i serologici care sunt sensibili \u0219i specifici pentru integritatea celulelor murale \u0219i pentru depistarea precoce a AAC\/BA.<\/p>\n<\/td>\n<\/tr>\n

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Data de \u00eencepere<\/p>\n<\/td>\n

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23.05.2023<\/p>\n<\/td>\n<\/tr>\n

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Perioada de implementare<\/p>\n<\/td>\n

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36 luni<\/p>\n<\/td>\n<\/tr>\n

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Valoarea total\u0103<\/p>\n<\/td>\n

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7,000,000,lei<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Prezentare rezultate proiect\u00a0 01.07.2023- 31.03.2026<\/strong><\/a><\/p>\n

\u00a0<\/p>\n

Rezultatele finale ob\u021binute de candida\u021bi \u00een urma finaliz\u0103rii procesului de recrutare \u0219i selec\u021bie pentru personalul care va fi \u00eencadrat suplimentar pe posturi \u00een afara organigramei \u00een cadrul proiectului \u201eIntramural cells as biomarkers and therapeutic targets for Alzheimer’s disease\u201d, contract de finan\u021bare nr. CF63\/14.11.2022.<\/a><\/p>\n

Rezultatele ob\u021binute de candida\u021bi \u00een urma finaliz\u0103rii celei de-a doua etape a procesului de recrutare \u0219i selec\u021bie \u2013 evaluarea CV-urilor pentru ocuparea posturilor in afara organigramei , din cadrul proiectului \u201eIntramural cells as biomarkers and therapeutic targets for Alzheimer\u2019s disease\u201d, contract de finan\u021bare nr. 760108\/23.05.2024;CF63\/14.11.2022<\/a><\/p>\n

Rezultate ob\u021binute de candida\u021bi \u00een urma finaliz\u0103rii primei etape a procesului de recrutare \u0219i selec\u021bie \u2013 verificarea de c\u0103tre comisia de evaluare \u0219i selec\u021bie a eligibilit\u0103\u021bii dosarelor depuse de c\u0103tre candida\u021bi pentru ocuparea posturilor \u00een afara organigramei \u00een cadrul proiectului \u201eIntramural cells as biomarkers and therapeutic targets for Alzheimer’s disease”, contract de finan\u021bare nr. 760108\/23.05.2023;CF63\/14.11.2022<\/a><\/p>\n

Anun\u021b privind procesul de recrutare \u0219i selec\u021bie pentru ocuparea unor posturi \u00een afara organigramei \u00een cadrul proiectului \u201eIntramural cells as biomarkers and therapeutic targets for Alzheimer’s disease\u201d, contract de finan\u021bare nr. CF63\/14.11.2022, Director de proiect:\u00a0 Prof.Univ.Dr.Roxana C\u0103rare.<\/a><\/p>\n

ERATA <\/a>– la anun\u021bul privind procesul de recrutare \u0219i selec\u021bie pentru ocuparea unor posturi \u00een afara organigramei, pentru desf\u0103\u0219urarea de activit\u0103\u021bi din cadrul proiectului \u201eIntramural cells as biomarkers and therapeutic targets for Alzheimer’s disease\u201d, contract de finan\u021bare nr. 760108\/23.05.2023,CF63 \/14.11.2022, Director de proiect:\u00a0 Prof.Univ.Dr.Roxana C\u0103rare<\/p>\n

Cerere<\/a><\/p>\n

Declaratie antecedente penale – Model orientativ<\/a><\/p>\n

Declaratie disponibilitate indeplinire atributii – Model orientativ<\/a><\/p>\n

Declaratie prelucrare date cu caracter personal – Model orientativ<\/a><\/p>\n

Rezultatele finale ob\u021binute de candida\u021bi \u00een urma finaliz\u0103rii procesului de recrutare \u0219i selec\u021bie pentru personalul care va fi \u00eencadrat suplimentar pe posturi \u00een afara organigramei \u00een cadrul proiectului \u201eIntramural cells as biomarkers and therapeutic targets for Alzheimer\u2019s disease\u201d, contract de finan\u021bare nr.760108\/23.05.2023;CF63\/14.11.2022<\/a><\/p>\n

Rezultatele ob\u021binute de candida\u021bi \u00een urma finaliz\u0103rii celei de-a doua etape a procesului de recrutare \u0219i selec\u021bie \u2013 evaluarea CV-urilor pentru ocuparea posturilor in afara organigramei , din cadrul proiectului \u201eIntramural cells as biomarkers and therapeutic targets for Alzheimer\u2019s disease\u201d, contract de finan\u021bare nr. 760108\/23.05.2024;CF63\/14.11.2022<\/a><\/p>\n

Rezultate ob\u021binute de candida\u021bi \u00een urma finaliz\u0103rii primei etape a procesului de recrutare \u0219i selec\u021bie \u2013 verificarea de c\u0103tre comisia de evaluare \u0219i selec\u021bie a eligibilit\u0103\u021bii dosarelor depuse de c\u0103tre candida\u021bi pentru ocuparea posturilor \u00een afara organigramei \u00een cadrul proiectului \u201eIntramural cells as biomarkers and therapeutic targets for Alzheimer\u2019s disease\u201d, contract de finan\u021bare nr. 760108\/23.05.2023<\/a><\/p>\n

Anun\u021b privind procesul de recrutare \u0219i selec\u021bie pentru ocuparea unor posturi \u00een afara organigramei \u00een cadrul proiectului \u201eIntramural cells as biomarkers and therapeutic targets for Alzheimer’s disease\u201d, contract de finan\u021bare nr. CF63\/14.11.2022, Director de proiect:\u00a0 Prof.Univ.Dr.Roxana C\u0103rare.<\/a><\/p>\n

Cerere<\/a><\/p>\n

Declaratie_antecedente_penale-model_orientativ<\/a><\/p>\n

Declaratie_disponibilitate_indeplinire_atributii_-_Model_orientativ<\/a><\/p>\n

Declaratie_prelucrare_date_cu_caracter_personal_-_model_orientativ<\/a><\/p>\n

\u00a0

Rezultatele finale ob\u021binute de candida\u021bi \u00een urma finaliz\u0103rii procesului de recrutare \u0219i selec\u021bie pentru personalul care va fi \u00eencadrat suplimentar pe posturi \u00een afara organigramei \u00een cadrul proiectului \u201eIntramural cells as biomarkers and therapeutic targets for Alzheimer’s disease\u201d, contract de finan\u021bare nr. CF63\/14.11.2022<\/a><\/strong><\/p>\n

Rezultatele ob\u021binute de candida\u021bi \u00een urma finaliz\u0103rii celei de-a doua etape a procesului de recrutare \u0219i selec\u021bie – evaluarea CV-urilor pentru ocuparea posturilor in afara organigramei , din cadrul proiectului \u201eIntramural cells as biomarkers and therapeutic targets for Alzheimer’s disease\u201d, contract de finan\u021bare nr. CF63\/14.11.2022<\/a><\/p>\n

Rezultate ob\u021binute de candida\u021bi \u00een urma finaliz\u0103rii primei etape a procesului de recrutare \u0219i selec\u021bie \u2013 verificarea de c\u0103tre comisia de evaluare \u0219i selec\u021bie a eligibilit\u0103\u021bii dosarelor depuse de c\u0103tre candida\u021bi pentru ocuparea posturilor \u00een afara organigramei \u00een cadrul proiectului \u201eIntramural cells as biomarkers and therapeutic targets for Alzheimer’s disease\u201d, contract de finan\u021bare nr. CF63\/14.11.2022<\/a><\/strong><\/p>\n

Anun\u021b privind procesul de recrutare \u0219i selec\u021bie pentru ocuparea unor posturi \u00een afara organigramei \u00een cadrul proiectului \u201eIntramural cells as biomarkers and therapeutic targets for Alzheimer’s disease\u201d, contract de finan\u021bare nr. CF63\/14.11.2022, Director de proiect:\u00a0 Prof.Univ.Dr.Roxana C\u0103rare.<\/a><\/p>\n

Cerere<\/a><\/p>\n

Declaratie_antecedente_penale-model_orientativ<\/a><\/p>\n

Declaratie_disponibilitate_indeplinire_atributii_-_Model_orientativ<\/a><\/p>\n

Declaratie_prelucrare_date_cu_caracter_personal_-_model_orientativ<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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\u00a0<\/p>\n

\u201ePNRR. Finan\u021bat de Uniunea European\u0103 \u2013 Urm\u0103toareaGenera\u021bieUE\u201d<\/p>\n

\u201eCon\u021binutul acestui material nu reprezint\u0103 \u00een mod obligatoriu pozi\u021bia oficial\u0103 a Uniunii Europene sau a Guvernului Rom\u00e2niei\u201d<\/p>\n

https:\/\/mfe.gov.ro\/pnrr\/<\/a> \u00a0\u00a0\u00a0 https:\/\/www.facebook.com\/PNRROficial\/ <\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"

\u00a0 Proiect Intramural cells as biomarkers and therapeutic targets for Alzheimer’s disease\u201d . Finan\u021bat \u00een cadrul Planului Na\u021bional de Redresare \u0219i Rezilien\u021b\u0103 a Rom\u00e2niei (PNRR) Apel nr.PNRR-III-C9-2022-I8 Pilon III: Cre\u0219tere inteligent\u0103, durabil\u0103 \u0219i favorabil\u0103 incluziunii, inclusiv coeziune economic\u0103, locuri de munc\u0103, productivitate, competitivitate, cercetare, dezvoltare \u0219i inovare \u0219i o pia\u021b\u0103 intern\u0103 care func\u021bioneaz\u0103 bine, cu […]<\/p>\n","protected":false},"author":25,"featured_media":0,"parent":21712,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"150,154","_relevanssi_noindex_reason":"","footnotes":""},"categories":[145,16],"tags":[],"class_list":["post-21714","page","type-page","status-publish","hentry","category-pagina-cercetare","category-pagina-sidebar"],"meta_box":[],"_links":{"self":[{"href":"https:\/\/umfst.ro\/en\/wp-json\/wp\/v2\/pages\/21714","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/umfst.ro\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/umfst.ro\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/umfst.ro\/en\/wp-json\/wp\/v2\/users\/25"}],"replies":[{"embeddable":true,"href":"https:\/\/umfst.ro\/en\/wp-json\/wp\/v2\/comments?post=21714"}],"version-history":[{"count":0,"href":"https:\/\/umfst.ro\/en\/wp-json\/wp\/v2\/pages\/21714\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/umfst.ro\/en\/wp-json\/wp\/v2\/pages\/21712"}],"wp:attachment":[{"href":"https:\/\/umfst.ro\/en\/wp-json\/wp\/v2\/media?parent=21714"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/umfst.ro\/en\/wp-json\/wp\/v2\/categories?post=21714"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/umfst.ro\/en\/wp-json\/wp\/v2\/tags?post=21714"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}