{"id":25020,"date":"2024-05-07T10:34:05","date_gmt":"2024-05-07T07:34:05","guid":{"rendered":"https:\/\/umfst.ro\/?page_id=25020"},"modified":"2024-09-20T12:58:44","modified_gmt":"2024-09-20T09:58:44","slug":"target","status":"publish","type":"page","link":"https:\/\/umfst.ro\/en\/universitate\/departament-proiecte-europene\/anunturi\/comisia-europeana\/target\/","title":{"rendered":"TARGET"},"content":{"rendered":"\t\t
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\u00a0<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
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Title of Project<\/p>\n<\/td>\n

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\u201eHealth virtual twins for the personalised management of stroke related to atrial fibrillation”<\/p>\n<\/td>\n<\/tr>\n

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Cod Proiect<\/p>\n<\/td>\n

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101136244 \u2014HORIZON-HLTH-2023-TOOL-05<\/p>\n<\/td>\n<\/tr>\n

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Nr Contract<\/p>\n<\/td>\n

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8390265\/07.12.2023<\/p>\n<\/td>\n<\/tr>\n

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Acronim<\/p>\n<\/td>\n

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TARGET<\/p>\n<\/td>\n<\/tr>\n

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Project Duration<\/p>\n<\/td>\n

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60 months<\/p>\n<\/td>\n<\/tr>\n

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Total budget value\/UMFST<\/p>\n<\/td>\n

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185.000,00 Euro –<\/strong><\/p>\n<\/td>\n<\/tr>\n

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Funding<\/p>\n<\/td>\n

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Horizon Europe<\/p>\n<\/td>\n<\/tr>\n

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Purpose and planning<\/p>\n<\/td>\n

The project aims to develop novel personalised, integrated, multi-scale computational models (virtual twins) and decision-support tools for the AF-related stroke pathway, starting from the healthy state, pathophysiology and disease onset, progression, treatment and recovery. The project aims to help prevent AF and AFRS, optimise acute management and rehabilitation, reduce long-term disability, provide a better quality of life for patients and caregivers, and lower healthcare costs. New observational data will be collected via 4 carefully designed prospective clinical studies, which will be used to test and validate the personalised tools and the virtual twin models using a clinical trial simulation (virtual\/in-silico), to demonstrate evidence of clinically meaningful results. The project will also help consolidate existing mechanistic virtual twin models of the heart, the brain and the neuromusculoskeletal system, enriching these twins to deliver more complex tasks, and supporting research to move towards a more integrated human virtual twin. It is a milestone project to improve the care and rehabilitation of patients with AF and AFRS, introducing a paradigm shift in risk prediction, diagnosis and management of the disease, and accelerating translational research into practice.\u00a0Project planning:\n

WP1 – Coordination and management. Start month M1, End month M60.<\/p>\n

WP2 – Stakeholder involvement and engagement. Start month M1, End month M60.<\/p>\n

WP3 Data integration and sharing. Start month M1, End month M60.<\/p>\n

WP4 Virtual twin development. Start month M1, End month M60.<\/p>\n

WP5 Risk prediction modelling of AF and AFRS in the virtual twin [Pillar I]. Start month M1, End month M60.<\/p>\n

WP6 Diagnosis and early management modelling of AFRS in the virtual twin [Pillar II]. Start month M1, End month M60.<\/p>\n

WP7 Modelling rehabilitation needs in the virtual twin of AFRS patients [Pillar III]. Start month M1, End month M60.<\/p>\n

WP8 Clinical studies and in-silico trials. Start month M1, End month M60.<\/p>\n

WP9 Dissemination, communication, and exploitation. Start month M1, End month M60.<\/p>\n<\/td>\n<\/tr>\n

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Main objectives<\/p>\n<\/td>\n

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The aim of the TARGET project is to accelerate translational research for the personalised management of the AF-related stroke pathway, starting from the healthy state, pathophysiology and disease onset, progression, treatment and recovery. For this, TARGET will develop integrated, multi-scale computational models (virtual twins) and tools.<\/p>\n

Specific Objectives (SO):<\/p>\n

-SO1: To assess the needs, understanding, and engagement with health virtual twin models and tools, to examine the potential barriers to their acceptance, and promote their adoption.<\/p>\n

-SO2: To develop multi-scale and multi-organ, dynamic, and interoperable virtual twins of AF and AFRS patients to accelerate translational research, enabling personalised and cost-effective management and rehabilitation of stroke patients.<\/p>\n

SO3. To develop and validate personalised virtual twin models for the dynamic risk prediction related to the underlying pathophysiology of AF and AFRS based on established and novel predisposing factors.<\/p>\n

SO4. To develop and validate personalised virtual twin models for diagnosis and management of AFRS, including treatment optimisation and prediction of functional outcomes and mortality.<\/p>\n

SO5. To develop and validate a personalised virtual twin model for rehabilitation to dynamically assess and predict outcomes in post-acute AFRS patients, focusing on functional outcomes, and individual treatment responses.<\/p>\n

SO6. To assess the developed virtual twin models for the AFRS pathway in a clinical trial simulation (virtual\/in-silico trial) and evaluate the impact of their use in a clinical application versus standard of care.<\/p>\n

SO7. To develop decision support tools for the AFRS pathway and a platform for data integration and sharing.<\/p>\n

SO8. To actively engage with the scientific community, disseminate the results to relevant stakeholders and maximise the exploitation of TARGET\u2019s outputs.<\/p>\n

\u00a0<\/strong><\/p>\n<\/td>\n<\/tr>\n

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Results<\/p>\n<\/td>\n

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-High level of acceptance and engagement with the virtual twin models and decision support tools for AF and stroke.<\/p>\n

-Development of multi-organ, multi-scale virtual twins that simulate the individual patient pathophysiology.<\/p>\n

-Development of personalised virtual twin models for dynamic risk prediction of AF and AFRS that consider the patient individual characteristics and medical and health status history.<\/p>\n

-Development of personalised virtual twin models for diagnosis and management, e.g., resumption of anticoagulation.<\/p>\n

-Development of personalised virtual twin models to identify rehabilitation needs and predict functional outcomes in post-acute AFRS patients.<\/p>\n

-Simulation of an in-silico trial, including selected interventions, to demonstrate outcome improvement when using the developed virtual twin models for the AFRS pathway in the in-silico clinical trial compared to standard-of-care.<\/p>\n

-Five decision support tools and centralised data platform, developed and operational.<\/p>\n

-Publishing and presenting TARGET\u2019s results in highly reputed scientific journals (>30 scientific papers in Q1 journals) and conferences (>80 oral or poster presentations).<\/p>\n

\u00a0<\/strong><\/p>\n

\u00a0<\/strong><\/p>\n

Participants<\/strong><\/p>\n

1 \u2013 LU; 2 \u2013 URV;3 \u2013 IMIM;4 \u2013 VUB;5 \u2013 RI;6 \u2013 INPT;6.1 \u2013 UPS;7 \u2013 SRL;8 \u2013 UMFST;<\/strong>9 \u2013 Isansys;10 \u2013 RUMC;11 \u2013 TUW;12 \u2013 SHS;13 \u2013 MOVERIM;14 \u2013 CERTH;15 \u2013 LUHFT;16 – A-A;17 \u2013 LHCH;18 – UoL<\/p>\n<\/td>\n<\/tr>\n

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Partener institution<\/p>\n<\/td>\n

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George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures<\/p>\n<\/td>\n<\/tr>\n

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Team:<\/p>\n<\/td>\n

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Name<\/p>\n<\/td>\n

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Role<\/p>\n<\/td>\n<\/tr>\n

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Prof. Benedek Theodora<\/p>\n<\/td>\n

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Project manager<\/p>\n<\/td>\n<\/tr>\n

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\u00a0<\/p>\n<\/td>\n

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Prof. Benedek Imre<\/p>\n<\/td>\n

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Experienced researcher<\/p>\n<\/td>\n<\/tr>\n

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\u00a0<\/p>\n<\/td>\n

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Conf. Florin Grosu<\/p>\n<\/td>\n

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Experienced researcher<\/p>\n<\/td>\n<\/tr>\n

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\u00a0<\/p>\n<\/td>\n

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Dr. Rat Nora<\/p>\n<\/td>\n

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Experienced researcher<\/p>\n<\/td>\n<\/tr>\n

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\u00a0<\/p>\n<\/td>\n

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Dr. Ioana Rodean<\/p>\n<\/td>\n

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Postdoc<\/p>\n<\/td>\n<\/tr>\n

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\u00a0<\/p>\n<\/td>\n

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Dr. Gerculy Renata<\/p>\n<\/td>\n

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Postdoc<\/p>\n<\/td>\n<\/tr>\n

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Dr. Rosca Aurelian<\/p>\n<\/td>\n

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PhD student<\/p>\n<\/td>\n<\/tr>\n

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\u00a0<\/p>\n<\/td>\n

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Dr. Theofana Mih\u0103il\u0103<\/p>\n<\/td>\n

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PhD student<\/p>\n<\/td>\n<\/tr>\n

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\u00a0<\/p>\n<\/td>\n

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Dr. Blindu Emanuel<\/p>\n<\/td>\n

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PhD student<\/p>\n<\/td>\n<\/tr>\n

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\u00a0<\/p>\n<\/td>\n

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Ma\u0219ca Violeta<\/p>\n<\/td>\n

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PhD student<\/p>\n<\/td>\n<\/tr>\n

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\u00a0<\/p>\n<\/td>\n

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Liliana Cojocariu<\/p>\n<\/td>\n

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Master student<\/p>\n<\/td>\n<\/tr>\n

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\u00a0<\/p>\n<\/td>\n<\/tr>\n

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Results<\/p>\n<\/td>\n

\u00a0<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Rezultatele finale<\/a> obtinute de candidati in urma finalizarii procesului de recrutare si selectie\u00a0 in cadrul proiectului ,,Health virtual twins for the personalised management of stroke related to atrial fibrillation \u2013 TARGET\u201d<\/p>

Rezultatele finale<\/a> obtinute de candidati in urma finalizarii celei de-a doua etape a procesului de recrutare si selectie \u2013 evaluarea CV-urilor in cadrul proiectului ,,Health virtual twins for the personalised management of stroke related to atrial fibrillation \u2013 TARGET<\/p>

Rezultate finale etapa 2, iulie 2024<\/a><\/p>

Rezultate etapa 1, iulie 2024<\/a><\/p>

Universitatea de Medicina, Farmacie, \u0218tiinte \u0219i Tehnologie \u201eGeorge Emil Palade\u201d din T\u00e2rgu Mure\u0219 anun\u021b\u0103 organizarea procesului de recrutare \u0219i selectie a xx membrii a echipei proiectului \u201eHealth virtual twins for the personalised management of stroke related to atrial fibrillation – TARGET\u201d, Contract de finantare nr.\u00a0 8390265\/07.12.2022 \u00een afara organigramei actuale a UMFST G.E. Palade T\u00e2rgu Mure\u0219
detalii<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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\u00a0<\/p>

Rezultatele finale<\/a> obtinute de candidati in urma finalizarii procesului de recrutare si selectie \u00een cadrul proiectului ,,Health virtual twins for the personalised management of stroke related to atrial fibrillation – TARGET”<\/p>

Rezultatele finale<\/a> obtinute de candidati in urma finalizarii celei de-a doua etape a procesului de recrutare si selectie – evaluarea CV-urilor in cadrul proiectului ,,Health virtual twins for the personalised management of stroke related to atrial fibrillation – TARGET”<\/p>

Rezultatele<\/a> obtinute de candidati in urma finalizarii celei de-a doua etape a procesului de recrutare si selectie – evaluarea CV-urilor in cadrul proiectului ,,Health virtual twins for the personalised management of stroke related to atrial fibrillation – TARGET”<\/p>

Rezultatele<\/a> obtinute de candidati in urma finalizarii primei etape a procesului de recrutare \u0219i selectie – verificarea de catre comisia de evaluare \u0219i selectie, a eligibilitatii dosarelor depuse de catre candidati pentru ocuparea posturilor vacante din cadrul proiectului 10 11 36244 \u201eHea lth virtual twins for the personalised management of stroke related to atrial fibrillation – TARGET\u201d Contract de finantare nr 8390265\/07.12. 2023, responsabil proiect prof. Dr. Theodora Benedek<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Universitatea de Medicina, Farmacie, \u0218tiinte \u0219i Tehnologie \u201eGeorge Emil Palade\u201d din T\u00e2rgu Mure\u0219 anun\u021b\u0103 organizarea procesului de recrutare \u0219i selectie a xx membrii a echipei proiectului \u201eHealth virtual twins for the personalised management of stroke related to atrial fibrillation – TARGET\u201d, Contract de finantare nr.  8390265\/07.12.2022 \u00een afara organigramei actuale a UMFST G.E. Palade T\u00e2rgu Mure\u0219
detalii<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

\u00a0 Title of Project \u201eHealth virtual twins for the personalised management of stroke related to atrial fibrillation” Cod Proiect 101136244 \u2014HORIZON-HLTH-2023-TOOL-05 Nr Contract 8390265\/07.12.2023 Acronim TARGET Project Duration 60 months Total budget value\/UMFST 185.000,00 Euro – Funding Horizon Europe Purpose and planning The project aims to develop novel personalised, integrated, multi-scale computational models (virtual twins) […]<\/p>\n","protected":false},"author":25,"featured_media":0,"parent":722,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"150,154","_relevanssi_noindex_reason":"","footnotes":""},"categories":[145,16],"tags":[],"class_list":["post-25020","page","type-page","status-publish","hentry","category-pagina-cercetare","category-pagina-sidebar"],"meta_box":[],"_links":{"self":[{"href":"https:\/\/umfst.ro\/en\/wp-json\/wp\/v2\/pages\/25020","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/umfst.ro\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/umfst.ro\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/umfst.ro\/en\/wp-json\/wp\/v2\/users\/25"}],"replies":[{"embeddable":true,"href":"https:\/\/umfst.ro\/en\/wp-json\/wp\/v2\/comments?post=25020"}],"version-history":[{"count":8,"href":"https:\/\/umfst.ro\/en\/wp-json\/wp\/v2\/pages\/25020\/revisions"}],"predecessor-version":[{"id":31183,"href":"https:\/\/umfst.ro\/en\/wp-json\/wp\/v2\/pages\/25020\/revisions\/31183"}],"up":[{"embeddable":true,"href":"https:\/\/umfst.ro\/en\/wp-json\/wp\/v2\/pages\/722"}],"wp:attachment":[{"href":"https:\/\/umfst.ro\/en\/wp-json\/wp\/v2\/media?parent=25020"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/umfst.ro\/en\/wp-json\/wp\/v2\/categories?post=25020"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/umfst.ro\/en\/wp-json\/wp\/v2\/tags?post=25020"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}