{"id":35068,"date":"2024-11-14T10:53:09","date_gmt":"2024-11-14T08:53:09","guid":{"rendered":"https:\/\/umfst.ro\/?post_type=proiect-european&#038;p=35068"},"modified":"2025-03-06T11:16:22","modified_gmt":"2025-03-06T09:16:22","slug":"noi-inhibitori-ai-proteinei-c-reactive-si-blocanti-de-disociere-pentru-uz-terapeutic-in-bolile-cardiovasculare","status":"publish","type":"proiect-european","link":"https:\/\/umfst.ro\/en\/universitate\/departament-proiecte-europene\/proiect-european\/noi-inhibitori-ai-proteinei-c-reactive-si-blocanti-de-disociere-pentru-uz-terapeutic-in-bolile-cardiovasculare\/","title":{"rendered":"Noi inhibitori ai proteinei C-reactive \u0219i blocan\u021bi de disociere pentru uz terapeutic \u00een bolile cardiovasculare"},"content":{"rendered":"<p>Obiectivele proiectului: Proiectarea de noi inhibitori de molecule mici poten\u021bial terapeutici, pe baza structurilor colinergice\/nictotinice \u0219i \u00een paralel, pentru a crea un compus terapeutic bazat pe sintetizarea modific\u0103rilor structurii chimice 1,6-bis (fosfocolin\u0103)-hexan, care poate preveni disocierea nativ\u0103 a CRP, anul\u00e2nd astfel efectele sale \u0219i protej\u00e2nd indivizii de boli.<\/p>\n\n\n\n<p>Ambele seturi de compu\u0219i vor fi bine caracterizate in vitro pentru capacitatea lor de a inhiba activit\u0103\u021bile biologice ale mCRP, inclusiv agregarea celulelor \u0219i trombocitelor, activarea macrofagelor, capacitatea inflamatorie etc.&nbsp;&nbsp;<\/p>\n\n\n\n<p>Cel mai eficient compus (set) care blocheaz\u0103 eficient activitatea mCRP in vitro va fi utilizat \u00eentr-un studiu de demonstrare a conceptului folosind modelul murin APOE\/-\/- de ateroscleroz\u0103\/tromboz\u0103.<\/p>","protected":false},"excerpt":{"rendered":"<p>Proiect de cercetare exploratorie finan\u021bat de UEFSCDI <\/p>","protected":false},"featured_media":37883,"template":"","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"29797,28292,34747,25342,18145,34801","_relevanssi_noindex_reason":"","footnotes":""},"sursa-finantare":[251],"class_list":["post-35068","proiect-european","type-proiect-european","status-publish","has-post-thumbnail","hentry","sursa-finantare-fonduri-nationale"],"meta_box":{"domeniu":"medicin\u0103","valoare_proiect":"1.198.029,00 lei","director_de_proiect":"Prof. dr. Slevin Mark","perioada_de_implementare":"04.01.2021 - 31.12.2023","website":""},"_links":{"self":[{"href":"https:\/\/umfst.ro\/en\/wp-json\/wp\/v2\/proiect-european\/35068","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/umfst.ro\/en\/wp-json\/wp\/v2\/proiect-european"}],"about":[{"href":"https:\/\/umfst.ro\/en\/wp-json\/wp\/v2\/types\/proiect-european"}],"version-history":[{"count":0,"href":"https:\/\/umfst.ro\/en\/wp-json\/wp\/v2\/proiect-european\/35068\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/umfst.ro\/en\/wp-json\/wp\/v2\/media\/37883"}],"wp:attachment":[{"href":"https:\/\/umfst.ro\/en\/wp-json\/wp\/v2\/media?parent=35068"}],"wp:term":[{"taxonomy":"sursa-finantare","embeddable":true,"href":"https:\/\/umfst.ro\/en\/wp-json\/wp\/v2\/sursa-finantare?post=35068"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}