{"id":49537,"date":"2026-08-18T11:23:14","date_gmt":"2026-08-18T08:23:14","guid":{"rendered":"https:\/\/umfst.ro\/"},"modified":"2026-08-20T15:25:53","modified_gmt":"2026-08-20T12:25:53","slug":"laboratorul-de-imunologie","status":"publish","type":"centru-ucsdt","link":"https:\/\/umfst.ro\/fr\/universitate\/cercetare\/unitatea-de-cercetare-stiintifica-si-dezvoltare-tehnologica\/ccamf\/laboratorul-de-imunologie\/","title":{"rendered":"Laboratorul de Imunologie"},"content":{"rendered":"

CCAMF \u2013 Laboratorul de Imunologie a fost construit \u0219i echipat \u00een 2015, datorit\u0103 proiectului POS CCE O 2.2.1-2013-1: CENTRU AVANSAT DE CERCETARI MEDICALE SI FARMACEUTICE \/ CCAMF \u2013 Nr. 1837\/48736. <\/strong>Laboratorul include dispozitive pentru separarea celulelor \/ modificare genetic\u0103 \/ cultur\u0103 \/ analiz\u0103: citometru cu flux cu 4 laser (sortator de celule BD FACSAria\u2122), sisteme de separare celular\u0103, ultracentrifug\u0103, sistem de electroporare, microscop confocal (Leica TCS SP8), microscoape inversate (seria Leica), contoare celulare \u0219i, de asemenea ,analizatoare bazate pe tehnici precum: – tehnologia xMAP (FlexMap 3D) \u0219i Array (pe biocipuri), ELISA, CLIA, nefelometrie, turbidemetrie, spectrofotometrie, coagulometrie \u0219i aggregometrie – linie complet\u0103 de electroforez\u0103 \/ bloting, sistem electroforetic automat pentru separarea \u0219i identificarea proteinelor (BioRad).<\/p>","protected":false},"excerpt":{"rendered":"

CCAMF \u2013 Laboratorul de Imunologie a fost construit \u0219i echipat \u00een 2015, datorit\u0103 proiectului POS CCE O 2.2.1-2013-1: CENTRU AVANSAT DE CERCETARI MEDICALE SI FARMACEUTICE \/ CCAMF \u2013 Nr. 1837\/48736. Laboratorul include dispozitive pentru separarea celulelor \/ modificare genetic\u0103 \/ cultur\u0103 \/ analiz\u0103: citometru cu flux cu 4 laser (sortator de celule BD FACSAria\u2122), sisteme […]<\/p>\n","protected":false},"author":25,"featured_media":43061,"parent":50942,"menu_order":0,"comment_status":"open","ping_status":"open","template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"41295,47914,45077,47483,40089,44442","_relevanssi_noindex_reason":"","footnotes":""},"class_list":["post-49537","centru-ucsdt","type-centru-ucsdt","status-publish","format-standard","has-post-thumbnail","hentry"],"meta_box":{"mail":"minodora.dobreanu@umfst.ro","telefon":"","adresa_centru":"","facebook":"","website_centru":"","echipa":"

Personalul laboratorului este dedicat activit\u0103\u021bilor de cercetare \u0219i preg\u0103tit s\u0103 ofere asisten\u021b\u0103 tehnic\u0103 \u0219i s\u0103 contribuie cu resurse intelectuale la diverse proiecte de cercetare.<\/p>\n

    \n
  1. Prof. Minodora Dobreanu, MD, PhD- https:\/\/orcid.org\/0000-0003-3214-3631<\/a><\/li>\n
  2. Assist. Prof. Adina Hu\u021banu, MD, PhD \u2013 https:\/\/orcid.org\/0000-0001-9798-1594<\/a><\/li>\n
  3. Biol. Doina Ramona Manu, PhD, MSc \u2013 https:\/\/orcid.org\/0000-0001-8374-4977<\/a><\/li>\n
  4. Biol. Liliana Demian, PhD - https:\/\/orcid.org\/0000-0002-5287-141X<\/a><\/li>\n
  5. Biol. M\u0103d\u0103lina Opric\u0103, MSc - https:\/\/orcid.org\/0000-0001-9530-3300<\/a><\/li>\n<\/ol>\n","servicii":"

    Tehnologiile xMAP<\/strong> ofer\u0103 detectarea simultan\u0103 a peste 500 de markeri \u00een suspensie sau pe suport solid, \u00eenso\u021bite de tehnici ELISA, CLIA<\/strong> \u0219i nephelometrice<\/strong>. Aceste tehnici permit determinarea simultan\u0103 a aspectelor calitative \u0219i cantitative ale unui num\u0103r mare de biomarkeri, semnale intracelulare, citokine, chemokine, factori de cre\u0219tere, markeri metabolici, receptori nucleari \u0219i factori de transcrip\u021bie.<\/p>\n

    Citometrul de flux<\/strong> identific\u0103 mai multe popula\u021bii celulare \u00eentr-un singur e\u0219antion. Aceasta maximizeaz\u0103 informa\u021biile ob\u021binute din cantit\u0103\u021bi limitate de prob\u0103 \u0219i cre\u0219te rentabilitatea testelor, deoarece poate reuni diverse informa\u021bii (egale cu num\u0103rul de canale de detec\u021bie) despre sute de mii de celule \u00eentr-o suspendare. Aplica\u021bii pentru analiza celulelor \u0219i elemente importante:<\/p>\n

    Separarea celular\u0103 \u2013 p\u00e2n\u0103 la 4 linii celulare pure, concomitent<\/p>\n

    Imunofenotipizare (markeri de suprafa\u021b\u0103 \u0219i marcatori intracelulari, m\u0103surarea celulelor rare circulante)<\/p>\n

    Func\u021bii celulare, apoptoz\u0103\/viabilitatea celular\u0103, analiza ciclului celular, proliferarea celular\u0103<\/p>\n

    BD FACSDiva software te ajut\u0103 s\u0103 treci de la analiz\u0103 la sortare. Sortatorul este echipat cu lasere de 405nm, 488nm, 561nm \u0219i 633nm \u0219i este capabil de detectare simultan\u0103 de p\u00e2n\u0103 la 9 culori. Popula\u021biile pot fi sortate \u00een p\u00e2n\u0103 la 4 tuburi, care pot fi de asemenea controlate termic prin utilizarea unui bloc de sortare \u00eenc\u0103lzit cu baie de ap\u0103 disponibil. Popula\u021biile sau celulele individuale pot fi, de asemenea, sortate direct pe lamele sau pe pl\u0103ci standard sau personalizate.<\/p>\n

    Microscopia confocal\u0103<\/strong> este o tehnic\u0103 de imagistic\u0103 optic\u0103 pentru cre\u0219terea rezolu\u021biei \u0219i contrastului optic, elimin\u00e2nd lumina neclar\u0103. Permite reconstruc\u021bia structurilor tridimensionale din imaginile ob\u021binute. Aplica\u021bii: scanare confocal\u0103 (imagini cu laser) ale specimenelor vii \u0219i fixe marcate cu fluorescen\u021b\u0103, precum \u0219i pentru m\u0103sur\u0103tori cantitative \u00een domeniul \u0219tiin\u021belor vie\u021bii. Puncte forte: Microscopia cu scanare cu laser confocal (CLSM) este una dintre serii de metode de generare a t\u0103ieturilor din probe microscopice prin intermediul opticii. P\u00e2n\u0103 la patru fluorofori plus o setare de c\u00e2mp luminos pot fi imagistice \u00een paralel sau secven\u021bial. Exist\u0103 patru detectoare interactive de emisii, oferind utilizatorului flexibilitate \u00een alegerea lungimii de und\u0103 de detectat. Beneficiul imagisticii confocale este un contrast crescut prin eliminarea neclaritatilor.<\/p>\n","activitati_de_cercetare":"

      \n
    1. Correlations between inflammatory, nutritional status and the degree of lung damage using artificial intelligence imaging software, among patiens with viral pneumonia due to SARS-Cov2 virus infection versus other types of viral pneumonia, Dr. H\u0103lmaciu Ioana, 2024-2025, No:164\/16\/10.01.2023.<\/li>\n
    2. Metabolic switches between lipolysis and glycolysis \u2013 evaluation of the influence on oxidative stress in two distinct animal models, Dr. Amalia Miklos (Pu\u0219ca\u0219), 2024-2025, No: 164\/23\/10.01.2023.<\/li>\n
    3. Nutritional evaluation and health effects of sustainable protein alternatives, Dr. Filip Cristina, 2024-2025, No.: 164\/14\/10.01.2023.<\/li>\n
    4. Intramural cells as biomarkers and therapeutic targets for Alzheimer's disease, PNRR-III-C9-2022-I8, 2023-2026, Professor Roxana C\u00e3rare<\/li>\n
    5. Cellular exploration of the cholesterol \u2013 oxidative stress \u2013 inflammation axis in coronary patients with high clinical suspicion for familial hypercholesterolemia. Ion-Bogdan M\u0103nescu, 164 \/ 19 \/ 10.01.2023, 2023-2024<\/li>\n
    6. Integrated evaluation of new molecular and plasma markers in aortopathy associated with bicuspid aortic valve in children, Dr. Amalia F\u0103g\u0103r\u0103\u0219an, 2023-2024, No: 163\/1\/10.01.2023.<\/li>\n
    7. Prevention of stroke by identifying blood biomarkers that correlate with histological changes specific to unstable carotid plaques, Dr. Balmo\u0219 Ioan, 2023-2024, No:164\/4\/10.01.2023.<\/li>\n
    8. Glial Cell-Derived Exosomes as Potential Biomarkers in Acute Ischemic Stroke, Timea Forro, UMFST T\u00e2rgu Mure\u0219, Grant 164\/1501.2023: 2023-2024<\/li>\n
    9. Opportunistic salpingectomy and gene expression involved in neoplasms. Postsalpingectomy ovarian function, Radu Teodora, 2024-2025, No: 171\/7\/09.01.2024.<\/li>\n
    10. Mapping Exposure-Induced Immune Effects: Connecting the Exposome and the Immunome (Eximious Project no. 874707), Horizon 2020-SC1-BHC-28-2019, Conf. Dr. Hora\u021biu Moldovan, 2020-2024, UMFST \u2013<\/li>\n
    11. Identification of Exosomal Markers in Newly Diagnosed Glioblastoma Patients, Georgiana-Mihaela \u0218erban, UMFST \u201cGeorge Emil Palade\u201d of T\u00e2rgu Mure\u0219, Grant 510\/16\/17.01.2022: 2022-2023<\/li>\n
    12. The Role of Exosomes Released by Bronchopulmonary Cancer Cells in the Formation of the Cerebral Pre-Metastatic Niche, Flaviu T\u0103ma\u0219, UMFST T\u00e2rgu Mure\u0219, Grant 510\/17\/17.01.2022; 2022-2023<\/li>\n
    13. The role of microbiota in the clinical evolution of Multiple Sclerosis patients treated with interferon beta; a complex approach (UEFSCDI grant) Dr. B\u0103rcu\u021bean Laura, 2022-2024.<\/li>\n
    14. Neurodegeneration in multiple sclerosis: innovative approach through morphological and functional biomarkers, neurofilament ELISA assay, Dr. Smaranda Maier, UMFST, 2022-2023<\/li>\n
    15. Determination of osteocalcin and N-telopeptide levels in crevicular fluid to assess the effectiveness of laser therapy in adult patiens with orthodontic treatment, Dr. Lumini\u021ba Laz\u0103r, UMFST, 2022-2023.<\/li>\n
    16. Evaluation of the effect of adipose tissue on inflammatory status in healthy adults between 20-35 years old (ADIPO), Dr. Bianca Kosovski, UMFST, 2022-2023<\/li>\n
    17. The diagnostic and prognostic role of glial fibrillary acidic protein in the dynamics of psychomotor development in patients with congenital heart malformations after cardiovascular surgery (PFAG-MCCop), Dr. L\u0103cr\u0103mioara Chiperi, UMFST, 2022-2023.<\/li>\n
    18. Novel C-reactive protein inhibitors and dissociation blockers for therapeutic use in cardiovascular diseases PN-III-P4-ID-PCE-2020-1540; 2021 \u2013 2023, Professor Mark Slevin<\/li>\n
    19. Clusterin as a new therapeutic target to improve clearance of vascular amyloid, PN-III-P4-ID-PCE2020-1622; 2021-2023, Professor Roxana C\u00e3rare<\/li>\n
    20. Evaluation of the cellular and humoral immune response and ACE2 gene polymorphisms for developing a stratification score for severe disease forms in patients with SARS-CoV-2 infection, grant 10126\/1\/17.12.2020; 2020-2023, Assistant Professor Adina Hu\u0163anu<\/li>\n
    21. Personalized Treatment of Glioblastomas: The Role of Exosome Identification, Professor Dr. Adrian B\u0103la\u0219a, UMFST \u201cG E Palade\u201d of T\u00e2rgu Mure\u0219, Grant 10126\/2\/ 17.12.2020: 2020-2023<\/li>\n
    22. The prognostic role of lymphocyte apoptosis and its impact in sepsis through the validation of biochemical and molecular markers (PALIS), Dr. Bianca Grigorescu, UMFST, 2021-2022.<\/li>\n
    23. Evolution of liver fibrosis and cardio-reno-metabolic correlations in non-alcoholic fatty liver disease in patiens with type 2 diabetes (FIB-DZ), Dr. Simona Cernea, UMFST, 2021-2022.<\/li>\n
    24. Prediction of the risk of preeclampsia and fetal growth restriction through serum parameters and Doppler (HPU), Dr. Chiril\u0103 Cristian, UMFST 2021-2022.<\/li>\n
    25. HTA - Dr. Nyulas Kinga \/ Conf. Univ. Dr. Nagy Eniko Nemes, UMFST, 2021-2022<\/li>\n
    26. Evaluation of the chronic toxicity of monosodium glutamate by investigating biochemical changes - design and validation of an experimental study on an animal model (MSG), Dr. Moldovan Octavia, UMFST, 2021.<\/li>\n
    27. Serum profile of proinflammatory and anti-inflammatory cytokines in patients with amyotrophic lateral sclerosis and their effect on disease progression (PSCPA-SLA), Dr. Mo\u021b\u0103\u021b\u0103ianu Anca, UMFST, 2020-2023<\/li>\n
    28. Study of inflammatory cytokines and associated genetic polymorphisms, in relation to the development and evolution of type 2 diabetes in adult patients, with and without obesity (CPD), Dr. Mariana Tilinca, UMFST, 2020-2022.<\/li>\n
    29. Evaluating the impact of antifibrotic medication in the first clinically relevant experimental model of atrial fibrillation. Creating a paradigm shift in experimental atrial fibrillation, PN III TE 155-2020-2021, Prof. Alina Scridon.<\/li>\n
    30. Identification of a panel of miRNAs for the diagnosis and prediction of atrial fibrillation. Clinical study in patients undergoing coronary artery bypass grafting (CABG-AF), PN III PD 66-2020-2021 Prof. Alina Serban<\/li>\n
    31. Evaluation of the incidence, persistence\/progression and efficacy of prophylaxis of subclinical contrast nephropathy in patients undergoing percutaneous coronary intervention (NIC), Dr. Cristina Somkereki,UMFST Targu Mures, 2020-2021.<\/li>\n
    32. Targeting a novel inflammation\/fibrosis pathway to improve diagnosis, prediction and treatment in atrial fibrillation, PN-III-P4-ID-PCE-2020-1283, Prof. Alina Scridon.<\/li>\n
    33. Obtaining and expertizing new biocompatible materials for medical applications (HEAMED), Dr. Kelemen Hajnal, PN-III-P1-1.2-PCCDI-2019, 2019-2020.<\/li>\n
    34. \u00a0<\/li>\n<\/ol>\n","publicatii_centru":"
        \n
      1. Anne Meyer, Oana R Oprea, Robert M\u00fcller, Markus Hoffmann, Matthias Orth, Tobias Fischer, Suzana Hatescu, Ana Maria Fotache, Elena C Preda, Minodora Dobreanu, Estimation of Sex- and Age-Specific Reference Values for Serum Creatinine Using Three Indirect Methods in a Multicenter Setting,The Journal of Applied Laboratory Medicine<\/em>, 2026; jfag016,\u00a0https:\/\/doi.org\/10.1093\/jalm\/jfag016<\/a>. IF2024=1,9<\/li>\n
      2. Anca A. Lilea, Oana R. Oprea, Albert Z. Barabas, Rares A. Renghes, Minodora Dobreanu Procalcitonin: The Laboratory Costs of Misused Tests , Journal of Laboratory Medicine. 2026, 72, 520-524, IF2024=1,8<\/li>\n
      3. Gy\u00f6rfi I, Oprea O, M\u0103nescu I, Dobreanu M. Variability of lipids and apolipoproteins results across platforms may impact cardiovascular risk assessment.Journal of Laboratory Medicine. 2026.\u00a0https:\/\/doi.org\/10.1515\/labmed-2025-0170<\/a>, IF2024=1,8<\/li>\n
      4. Gy\u00f6rfi I, M\u0103nescu IB, Oprea OR, Curici A, Fotache AM, Dobreanu M. Toward accurate LDL-cholesterol estimation: platform-specific, population-based equations outperform Friedewald in two independent cohorts. Scandinavian Journal of Clinical and Laboratory Investigation. 2025 Nov 85(8):660-669, https:\/\/doi.org\/10.1080\/00365513.2025.2592875<\/a> , IF2024=1,4.<\/li>\n
      5. Preda EC, Oprea OR, Barabas AZ, Fotache AM, Dobreanu M. When equations disagree: the impact of creatinine-based eGFR in CKD diagnosis and reclassification. BMC nephrology. 2025 Nov 18;26(1):647, https:\/\/doi.org\/10.1186\/s12882-025-04584-4<\/a> , IF2024=2,4.<\/li>\n
      6. Manu DR, B\u01cela\u015fa R, Pruteanu L-L, Curean V, Barbu-Tudoran L, \u015eerban G-M, Chinezu R, B\u0103la\u015fa A. Identification of distinct profiles of glioblastoma through the immunocapture of extracellular vesicles from patient plasma. PLoS ONE. 2025; 20(3): e0315890. https:\/\/doi.org\/10.1371\/journal.pone.0315890<\/a><\/li>\n
      7. Manu DR, Portan DV, Vu\u0163\u0103 M, Dobreanu M. Influence of Scaffold Structure and Biomimetic Properties on Adipose Stem Cell Homing in Personalized Reconstructive Medicine.\u00a0Biomimetics. 2025; 10(7):438. https:\/\/doi.org\/10.3390\/biomimetics10070438<\/a><\/li>\n
      8. Mates IM, Geanta V, Manu D, Kelemen H, Onici AE, Mirza-Rosca JC, Voiculescu I. TaMoNbTiZr Multielement Alloy for Medical Instruments.\u00a0Materials. 2025; 18(8):1876. https:\/\/doi.org\/10.3390\/ma18081876<\/a><\/li>\n
      9. Mosora O, Maier S, Manu D, B\u0103rcu\u021bean L, Roman M, Dumitreas\u0103 M, B\u0103la\u0219a R. Exosomal microRNAs as Early Transition Biomarkers from Recurrent-Remissive to Secondary Progressive Multiple Sclerosis.\u00a0International Journal of Molecular Sciences. 2025; 26(8):3889. https:\/\/doi.org\/10.3390\/ijms26083889<\/a><\/li>\n
      10. Ion Bogdan Manescu, Sara Thomas, Daniel G\u00eerlea, Liliana Demian, Ana Maria Fotache, Minodora Dobreanu, Immunometabolic profiling of human monocytes in response to lipid exposure, Revista Rom\u00e2na de Medicina de Laborator 2025; 33(3):157\u2013168, https:\/\/reference-global.com\/article\/10.2478\/rrlm-2025-0021<\/a> .<\/li>\n
      11. Laslo A, Boghi\u021boiu TG, Chinezu L, Manu D, Ivanescu DA, Cordo\u0219 BA, Wilson MR, Banescu C, Fryer JD, Verma A, Dewing JM, Carare RO. Intrahippocampally Injected Human Recombinant Clusterin Reduces Amyloid-\u03b2 Aggregate Size in Cerebral Arteriole Walls of Clusterin Knockout Mice. Neuropathol Appl Neurobiol. 2025 Oct;51(5):e70037. https:\/\/doi.org\/10.1111\/nan.70037<\/a><\/li>\n
      12. H\u0103lmaciu I, V\u0103sie\u0219iu AM, Manea A, Dragomir A, Tripon I, Vunvulea V, Boeriu C, Rus A, Dobreanu M. Artificial intelligence algorithms based approach in evaluating COVID-19 patients and management. The Journal of Critical Care Medicine, 2025;11(3): 247-256.https:\/\/doi.org\/10.2478\/jccm-2025-0032<\/a><\/li>\n
      13. Contac, L.-R.; Pop, S.I.; Dobreanu, M.; Oprica, M.; Voidazan, S.; Bica, C.I. Salivary Cortisol as a Biomarker for Assessing Fear and Anxiety in Patients with Molar\u2013Incisor Hypomineralization.Diagnostics<\/em>\u00a02025,\u00a015<\/em>, 489. doi:\u00a03390\/diagnostics15040489<\/a><\/li>\n
      14. Irina M. Matran , Daniela l. Muntean , Sabrina N. Munteanu , Liliana Demian , Cristina M. Pantea, Monica Tarcea, Nutrivigilance in emergency food products, Farmacia 2025, Vol.73 (5), 1073-1080, https:\/\/doi.org\/10.31925\/farmacia.2025.5.2<\/a><\/li>\n
      15. Lumini\u021ba Laz\u0103r, Dora-Maria Popescu, Timea Dak\u00f3, Mihaela Moisei, Sorin Nicolae Gheorghe, Anamaria Bud, M\u0103d\u0103lina Oprica, Mariana P\u0103curar, Ana-Petra Laz\u0103r, Evaluation of lase therapy during orthodontic treatment by determining N-telopeptide levels in gingival crevicular fluid, Medicina 2025, 61, 2170.<\/li>\n
      16. Timea Dak\u00f3, Lumini\u021ba Laz\u0103r, Petra \u0218urlin, Dora-Maria Popescu, Anamaria Bud, Alexandru Vlasa, M\u0103d\u0103lina Oprica, Sorina Mihaela Solomon, Ana-Petra Laz\u0103r, Determination of Osteocalcin levels in gingival crevicular fluid to assess the effectiveness of laser therapy in patients with orthodontic treatment, Biomedicines 2025, 13, 2803.<\/li>\n
      17. M\u0103nescu IB, Gabor MR, Moldovan GV, Hadadi L, Hu\u021banu A, B\u0103nescu C, Dobreanu M. An 8-SNP LDL Cholesterol Polygenic Score: Associations with Cardiovascular Risk Traits, Familial Hypercholesterolemia Phenotype, and Premature Coronary Heart Disease in Central Romania.\u00a0International Journal of Molecular Sciences. 2024; 25(18):10038. https:\/\/doi.org\/10.3390\/ijms251810038<\/a><\/li>\n
      18. Koc DC, M\u0103nescu IB, M\u0103nescu M, Dobreanu M. A Review of the Prognostic Significance of Neutrophil-to-Lymphocyte Ratio in Nonhematologic Malignancies.\u00a0Diagnostics. 2024; 14(18):2057. https:\/\/doi.org\/10.3390\/diagnostics14182057<\/a><\/li>\n
      19. M\u0103nescu IB, Demian L, Dobreanu M. Low-Density Lipoprotein Cholesterol Gymnastics: Exploring the Advantages and Limitations of the Friedewald, Martin\u2013Hopkins, and Sampson Equations for Personalized Lipid Management.\u00a0Journal of Personalized Medicine. 2024; 14(9):1000. https:\/\/doi.org\/10.3390\/jpm14091000<\/a><\/li>\n
      20. Andrejkovits \u00c1V, Hu\u021banu A, Manu DR, Dobreanu M, V\u0103sie\u0219iu AM. Dynamic Changes in Lymphocyte Populations and Their Relationship with Disease Severity and Outcome in COVID-19.\u00a0International Journal of Molecular Sciences. 2024; 25(22):11921. https:\/\/doi.org\/10.3390\/ijms252211921<\/a><\/li>\n
      21. M\u0103nescu IB, M\u0103nescu M, B\u0103rcu\u021bean LI, Demian L, Dobreanu M. Short-Term Atorvastatin Therapy in Healthy Individuals Results in Unaltered Plasma MMP Levels and Disrupted MMP-7 Correlation with Blood Lipids and Blood Count-Derived Inflammatory Markers.\u00a0Journal of Clinical Medicine. 2024; 13(16):4743. https:\/\/doi.org\/10.3390\/jcm13164743<\/a><\/li>\n
      22. LeaBeltzig,\u00a0Markus\u00a0Christmann,\u00a0Minodora\u00a0Dobreanu,\u00a0Bernd\u00a0Kaina, Genotoxic and Cytotoxic Activity of Fisetin on Glioblastoma Cells, Anticancer Research, 2024,\u00a044\u00a0(3)\u00a0901-910;\u00a0DOI:\u00a021873\/anticanres.16884<\/li>\n
      23. Vic\u0103, M.L.; Dobreanu, M.; Curocichin, G.; Matei, H.V.; B\u00e2lici, \u0218.; Vu\u0219can, M.E.; Chiorean, A.D.; Nicula, G.Z.; Pavel Mironescu, D.C.; Leucu\u021ba, D.C.; et al. The Influence of HLA Polymorphisms on the Severity of COVID-19 in the Romanian Population. J. Mol. Sci.<\/em>\u00a02024,\u00a025<\/em>, 1326. https:\/\/doi.org\/10.3390\/ijms25021326<\/a><\/li>\n
      24. Kosovski I.B., Ghiga D.,Ciurea C.N., Cucoranu D.C., Demian L., Gliga F.I., Bac\u00e2rea A., Evaluation of Fasting Glucose-Insulin-C-Peptide-Derived Metabolic Indices for Identifying Metabolic Syndrome in Young, Healthy Adults, Nutrients 2024, 16, 2135. https:\/\/doi.org\/10.3390\/nu16132135<\/a><\/li>\n
      25. Cristina Somkereki, Tunde Renata Nicoar\u0103, M\u0103d\u0103lina Oprica, Liliana Demian, Alina Scridon, Agreement between different eGFR equations in diagnosing contrast-induced acute kidney injury in patients undergoing elective coronary or peripheral angiography, Revista Rom\u00e2n\u0103 de Medicin\u0103 de Laborator 2024; 32(4):315-320.<\/li>\n
      26. Cristina Somkereki, Tunde Renata Nicoar\u0103, M\u0103d\u0103lina Oprica, Liliana Demian, Alina Scridon, Predictors and Consequences of Subclinical Renal Impairment in Patients with Vascular Disease, Journal of Cardiovascular Emergencies 2024; 10(4):133-141<\/li>\n
      27. Paul-Adrian C\u0103lburean, Silvia Lupu, Adina Hu\u021banu, M\u0103d\u0103lina Oprica, Diana Roxana Opri\u0219, Alexandru Stan, Anda-Cristina Scurtu, David Ani\u021bei, Marius Harpa, Klara Br\u00eenzaniuc, Hora\u021biu Suciu & L\u00e1szl\u00f3 Hadadi, Natriuretic peptides and soluble ST2 improves echocardiographic diagnosis of elevated left ventricular filling pressures, Scientific Reports 2024; 14:22171<\/li>\n
      28. Timea Forr\u00f3; Doina Ramona Manu; Lucian Barbu-Tudoran; Rodica B\u0103la\u0219a Astrocyte Dysfunction Reflected in Ischemia-Induced Astrocyte-Derived Extracellular Vesicles: A Pilot Study on Acute Ischemic Stroke Patients, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES\u00a0\u00a02024, Vol:\u00a025\u00a0:\u00a022, DOI:\u00a010.3390\/ijms252212471<\/li>\n
      29. Flaviu Tamas; Corina I Tamas; Bogdan A. Suciu; Doina R Manu; Alina R Cehan; Adrian F Balasa Comparative Analysis of Inflammatory Indexes in Lung Cancer Patients With and Without Brain Metastases, CUREUS JOURNAL OF MEDICAL SCIENCE\u00a0\u00a02024, Volume:\u00a016\u00a0\u00a0Issue:\u00a05, e60921\u00a0\u00a0DOI:\u00a010.7759\/cureus.60921<\/li>\n
      30. Timea Forr\u00f3; Doina Ramona Manu; Ovidiu-Lucian B\u0103jenaru; Rodica B\u0103la\u0219a GFAP as Astrocyte-Derived Extracellular Vesicle Cargo in Acute Ischemic Stroke Patients-A Pilot Study, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES\u00a0\u00a0Volume:\u00a025\u00a0\u00a0Issue:\u00a011, 2024, DOI:\u00a010.3390\/ijms25115726<\/li>\n
      31. Ylenia Pastorello; Doina Manu; Xenia Sawkulycz; Vittorio Caprio; Claudia Banescu; Minodora Dobreanu; Lawrence Potempa; Mario Di Napoli; Mark Slevin mCRP-Induced Focal Adhesion Kinase-Dependent Monocyte Aggregation and M1 Polarization, Which Was Partially Blocked by the C10M Inhibitor, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES\u00a0\u00a02024 Volume:\u00a025\u00a0\u00a0Issue:\u00a06, DOI:\u00a010.3390\/ijms25063097<\/li>\n
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      33. Kaller R,\u00a0\u00a0Russu E,\u00a0\u00a0Arb\u0103nas E.M,\u00a0\u00a0Muresan A.V,\u00a0\u00a0Jakab M , Ciucanu C.C,\u00a0\u00a0Arb\u0103nas E.M,\u00a0\u00a0Suciu B.A, Hosu I,\u00a0\u00a0Demian L,\u00a0\u00a0Horv\u00e1th E.,\u00a0Intimal CD31-Positive Relative Surfaces Are Associated with Systemic Inflammatory Markers and Maturation of Arteriovenous Fistula in Dialysis Patients.\u00a0Journal of Clinical Medicine<\/a>2023; 12(13):4419, doi:\u00a03390\/jcm12134419<\/a>.<\/li>\n
      34. Doina Ramona Manu; Mark Slevin; Laura Barcutean; Timea Forro; Tudor Boghitoiu; Rodica Balasa, Astrocyte Involvement in Blood-Brain Barrier Function: A Critical Update Highlighting Novel, Complex, Neurovascular Interactions, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, Volume:\u00a024\u00a0\u00a0Issue:\u00a024, DOI:\u00a010.3390\/ijms242417146<\/li>\n
      35. Smaranda Maier; Laura Barcutean; Sebastian Andone; Doina Manu; Emanuela Sarmasan; Zoltan Bajko; Rodica Balasa Recent Progress in the Identification of Early Transition Biomarkers from Relapsing-Remitting to Progressive Multiple Sclerosis, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, Vol:\u00a024\u00a0\u00a0Issue:\u00a05, DOI:\u00a010.3390\/ijms24054375<\/li>\n
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      37. Alina Scridon, Cristina Somkereki, Tunde Renata Nicoar\u0103, M\u0103d\u0103lina Oprica, Liliana Demian, Neutrophil gelatinase-associated lipocalin monitoring reveals persistent subclinical kindey injury following intraarterial administration of iodinated contrast agents, Scientific Reports, 2022, 12:19464<\/li>\n
      38. Georgiana \u0218erban; Flaviu T\u0103ma\u0219; Rodica B\u0103la\u0219a; Doina Manu; Corina T\u0103ma\u0219; Adrian B\u0103la\u0219a Prognostic Factors of Survival in Glioblastoma Multiforme Patients-A Retrospective Study, DIAGNOSTICS, 2022, Vol:12, Issue:11, DOI:10.3390\/diagnostics12112630<\/li>\n
      39. Chel\u0103rescu Simina, Petra \u0218urlin, Mioara Decusar\u0103, M\u0103d\u0103lina Oprica, Eugen Bud, Elina Teodorescu, Mahmoud Nabil Elsaafin, Mariana P\u0103curar, Evaluation\u00a0of IL1\u03b2 and IL6 Gingival Crevicular Fluid Levels during the Early Phase of Orthodontic Tooth Movement in Adolescents and Young Adults, Applied Sciences, 2021, 11(2)\/521<\/li>\n
      40. Hu\u021banu A, Dobreanu M. Antibody response after SARS-CoV-2 mRNA vaccine in na\u00efve and previously infected healthcare workers. Health Problems of Civilization. 2022;16(1):48-56. https:\/\/doi.org\/10.5114\/hpc.2021.111783<\/a><\/li>\n
      41. Hu\u021banu, A.; Manu, D.; Gabor, M.R.; V\u0103sie\u0219iu, A.M.; Andrejkovits, A.V.; Dobreanu, M. Dynamic Evaluation of Natural Killer Cells Subpopulations in COVID-19 Patients.\u00a0 J. Mol. Sci.<\/em>2022,\u00a023<\/em>, 11875. https:\/\/doi.org\/10.3390\/ijms231911875<\/a><\/li>\n
      42. Hu\u021banu A, Georgescu AM, Void\u0103zan S, Andrejkovits AV, Negrea V, Dobreanu M. Low Serum Vitamin D in COVID-19 Patients Is Not Related to Inflammatory Markers and Patients\u2019 Outcomes\u2014A Single-Center Experience and a Brief Review of the Literature.Nutrients<\/em>. 2022; 14(10):1998. https:\/\/doi.org\/10.3390\/nu14101998<\/a><\/li>\n
      43. Lumini\u021ba Laz\u0103r; Doina Ramona Manu; Timea Dako; Maria-Alexandra M\u00e2r\u021bu; Mircea Suciu; Alina Ormeni\u0219an; Mariana P\u0103curar; Ana-Petra Laz\u0103r, Effects of Laser Application on Alveolar Bone Mesenchymal Stem Cells and Osteoblasts: An In Vitro Study, DIAGNOSTICS, 2022, Vol:\u00a012\u00a0\u00a0Issue:\u00a010, DOI:\u00a010.3390\/diagnostics12102358<\/li>\n
      44. Rodica Balasa; Smaranda Maier; Adina Hutanu; Septimiu Voidazan; Sebastian Andone; Mirela Oiaga; Doina Manu, Cytokine Secretion Dynamics of Isolated PBMC after Cladribine Exposure in RRMS Patients, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES\u00a0\u00a02022, Volume:\u00a023\u00a0\u00a0Issue:\u00a018, DOI:\u00a010.3390\/ijms231810262\u00a0SEP\u00a0\u00a0<\/li>\n
      45. Feier AM, Portan D, Manu DR, Kostopoulos V, Kotrotsos A, Strnad G, Dobreanu M, Salcudean A, Bataga T. Primary MSCs for Personalized Medicine: Ethical Challenges, Isolation and Biocompatibility Evaluation of 3D Electrospun and Printed Scaffolds.Biomedicines<\/em>. 2022; 10(7):1563. https:\/\/doi.org\/10.3390\/biomedicines10071563<\/a><\/li>\n
      46. Flaviu T\u0103ma\u0219; Rodica B\u0103la\u0219a; Doina Manu; Gabriel Gyorki; Rare\u0219 Chinezu; Corina T\u0103ma\u0219; Adrian B\u0103la\u0219a, The Importance of Small Extracellular Vesicles in the Cerebral Metastatic Process, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, \u00a0\u00a0Volume:\u00a023\u00a0\u00a0Issue:\u00a03, DOI:\u00a010.3390\/ijms23031449<\/li>\n
      47. Dobreanu M, Manu DR, M\u0103nescu IB, Gabor MR, Hu\u0163anu A, B\u0103rcu\u0163ean L and B\u0103la\u015fa R Treatment With Cladribine Selects IFN\u03b3+IL17+ T Cells in RRMS Patients \u2013 An In Vitro Study. Front. Immunol. 2021, 12:743010, https:\/\/doi.org\/10.3389\/fimmu.2021.743010<\/a><\/li>\n
      48. Hu\u021banu A, Georgescu AM, Andrejkovits AV, Au W, Dobreanu M. Insights into Innate Immune Response Against SARS-CoV-2 Infection. Rev Romana Med Lab. 2021;29(3):255-69, DOI:10.2478\/rrlm-2021-0022<\/li>\n
      49. Moldovan V, B\u0103nescu C, Dobreanu M. Genetic Diagnostic Approaches in Familial Hypercholesterolemia Evaluation. Rev Romana Med Lab. 2021;29(3):319-25, DOI:10.2478\/rrlm-2021-0025<\/li>\n
      50. Adina Hu\u021banu, Mihaela Iancu, Minodora Dobreanu, Oana Oprea, \u0218tefan Barbu, Smaranda Maier, Amelia Tero-Vescan, Zoltan Bajko, Rodica B\u0103la\u0219a, Extended lipid profile in Romanian ischemic stroke patients in relationship with stroke severity and outcome: a path analysis model, Arch Med Sci 2021;17(4):864\u2013873, https:\/\/doi.org\/10.5114\/aoms.2019.89302<\/a><\/li>\n
      51. Hu\u021banu A, Zaharia M, Farczadi L, Pa\u0219canu IM, Pop RM, Dobreanu M. Evaluation of Plasma AA\/DHA+EPA Ratio in Obese Romanian Children.\u00a0Rev Romana Med Lab. 2021;29(2):165-78, https:\/\/sciendo.com\/article\/10.2478\/rrlm-2021-0002<\/a><\/li>\n
      52. Rodica Balasa; Laura Barcutean; Oana Mosora; Doina Manu Reviewing the Significance of Blood-Brain Barrier Disruption in Multiple Sclerosis Pathology and Treatment, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, Vol: 22 Issue:\u00a016 DOI:\u00a010.3390\/ijms22168370<\/li>\n
      53. Manescu IB, Pavelea O, Dobreanu M. Troubleshootings in RNA extraction \u2013 back to basic chemistry. Rev Romana Med Lab. 2020;28(4):441-5. DOI:10.2478\/rrlm-2020-0034, https:\/\/doi.org\/10.2478\/rrlm-2020-0034<\/a><\/li>\n
      54. Moldovan V, Banescu C, Dobreanu M. Molecular diagnosis methods in familial hypercholesterolemia. Anatol J Cardiol. 2020;23(3):120-127, DOI: https:\/\/doi.org\/10.14744\/anatoljcardiol.2019.95038<\/a><\/li>\n
      55. Manescu IB, Manu DR, Serban GM, Dobreanu M. Variability of ex-vivo stimulated T-cells secretory profile in healthy subjects. Rev Romana Med Lab. 2020;28(1):75-89. DOI:10.2478\/rrlm-2020-0004, https:\/\/doi.org\/10.2478\/rrlm-2020-0004<\/a><\/li>\n
      56. Adina Hutanu, Mihaela Iancu, Smaranda Maier, Rodica Balasa, Minodora Dobreanu. Plasma biomarkers as potential predictors of functional dependence in daily life activities after ischemic stroke: A single center study, Annals of Indian Academy of Neurology, 2020, 22(3), p.496-503, https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7657279\/<\/a><\/li>\n
      57. Anca Meda Georgescu, Claudia Banescu, Razvan Azamfirei, Adina Hutanu, Valeriu Moldovan, Iudita Badea, Septimiu Voidazan, Minodora Dobreanu, Ioana Raluca Chirtes, Leonard Azamfirei, Evaluation of TNF-\u03b1 genetic polymorphisms as predictors for sepsis susceptibility and progression. BMC Infect Dis, 2020, 20, https:\/\/doi.org\/10.1186\/s12879-020-4910-6<\/a><\/li>\n
      58. Adrian B\u0103la\u0219a; Georgiana \u0218erban; Rare\u015f Chinezu; Corina Hurghi\u0219; Flaviu T\u0103ma\u0219; Doina Manu, The Involvement of Exosomes in Glioblastoma Development, Diagnosis, Prognosis, and Treatment, BRAIN SCIENCES 2020, Vol: 10 Issue: 8, DOI: 10.3390\/brainsci10080553<\/li>\n
      59. Rodica Balasa; Laura Barcutean; Adrian Balasa; Anca Motataianu; Corina Roman-Filip; Doina Manu The action of TH17 cells on blood brain barrier in multiple sclerosis and experimental autoimmune encephalomyelitis, HUMAN IMMUNOLOGY, 2020, Vol:\u00a081\u00a0\u00a0Issue:\u00a05:p.\u00a0237-243\u00a0\u00a0DOI:\u00a010.1016\/j.humimm.2020.02.009<\/li>\n
      60. \u00a0<\/li>\n<\/ol>\n","patente_brevete_de_inventie":""},"_links":{"self":[{"href":"https:\/\/umfst.ro\/fr\/wp-json\/wp\/v2\/centru-ucsdt\/49537","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/umfst.ro\/fr\/wp-json\/wp\/v2\/centru-ucsdt"}],"about":[{"href":"https:\/\/umfst.ro\/fr\/wp-json\/wp\/v2\/types\/centru-ucsdt"}],"author":[{"embeddable":true,"href":"https:\/\/umfst.ro\/fr\/wp-json\/wp\/v2\/users\/25"}],"replies":[{"embeddable":true,"href":"https:\/\/umfst.ro\/fr\/wp-json\/wp\/v2\/comments?post=49537"}],"version-history":[{"count":1,"href":"https:\/\/umfst.ro\/fr\/wp-json\/wp\/v2\/centru-ucsdt\/49537\/revisions"}],"predecessor-version":[{"id":50936,"href":"https:\/\/umfst.ro\/fr\/wp-json\/wp\/v2\/centru-ucsdt\/49537\/revisions\/50936"}],"up":[{"embeddable":true,"href":"https:\/\/umfst.ro\/fr\/wp-json\/wp\/v2\/centru-ucsdt\/50942"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/umfst.ro\/fr\/wp-json\/wp\/v2\/media\/43061"}],"wp:attachment":[{"href":"https:\/\/umfst.ro\/fr\/wp-json\/wp\/v2\/media?parent=49537"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}