{"id":49539,"date":"2026-08-18T11:23:32","date_gmt":"2026-08-18T08:23:32","guid":{"rendered":"https:\/\/umfst.ro\/"},"modified":"2026-08-18T11:23:33","modified_gmt":"2026-08-18T08:23:33","slug":"laboratorul-de-morfologie-normala-si-patologica","status":"publish","type":"centru-ucsdt","link":"https:\/\/umfst.ro\/hu\/universitate\/cercetare\/unitatea-de-cercetare-stiintifica-si-dezvoltare-tehnologica\/laboratorul-de-morfologie-normala-si-patologica\/","title":{"rendered":"Laboratorul de Morfologie Normal\u0103 \u0219i Patologic\u0103"},"content":{"rendered":"

Rolul acestui laborator este de a asigura suportul tehnic \u0219i de expertiz\u0103 \u00een ceea ce prive\u0219te componenta de morfologie aferent\u0103 unei largi variet\u0103\u021bi de proiecte de cercetare, at\u00e2t studii experimentale, c\u00e2t \u0219i studii clinice. \u00cen cadrul acestui laborator oferim suport tehnic de \u00eenalt\u0103 calitate, consultan\u021b\u0103 profesional\u0103, evaluare morfologic\u0103 a pieselor, interpretare de date \u0219i achizi\u021bie de imagini ale lamelor histologice. Infrastructura laboratorului permite histoprocesarea complet\u0103 \u0219i standardizat\u0103 a \u021besuturilor, precum \u0219i realizarea de studii de imunohistochimie de \u00eenalt\u0103 calitate. Pentru examinarea lamelor, laboratorul dispune de microscoape moderne, precum \u0219i de un sistem de microdisec\u021bie laser, un microscop cu fluorescen\u021b\u0103 \u0219i un microscop cu sistem de scanare \u0219i achizi\u021bionare a imaginilor microscopice de ultim\u0103 genera\u021bie.<\/p>\n\n\n\n

Domeniile principale de interes \u0219i expertiz\u0103 sunt: patologia endocrin\u0103 (glanda hipofiz\u0103, tiroid\u0103, suprarenal\u0103), patologia urologic\u0103, neuropatologia (boli neurodegenerative, boala Alzheimer), rolul \u021besutului adipos micro-fragmentat ca \u0219i sistem de \u201cdrug-delivery\u201d pentru medica\u021bia oncologic\u0103.<\/p>","protected":false},"excerpt":{"rendered":"

Rolul acestui laborator este de a asigura suportul tehnic \u0219i de expertiz\u0103 \u00een ceea ce prive\u0219te componenta de morfologie aferent\u0103 unei largi variet\u0103\u021bi de proiecte de cercetare, at\u00e2t studii experimentale, c\u00e2t \u0219i studii clinice. \u00cen cadrul acestui laborator oferim suport tehnic de \u00eenalt\u0103 calitate, consultan\u021b\u0103 profesional\u0103, evaluare morfologic\u0103 a pieselor, interpretare de date \u0219i achizi\u021bie […]<\/p>\n","protected":false},"author":25,"featured_media":43064,"parent":17078,"menu_order":0,"comment_status":"open","ping_status":"open","template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"21477,35486,44030,38264,43428,35235","_relevanssi_noindex_reason":"","footnotes":""},"class_list":["post-49539","centru-ucsdt","type-centru-ucsdt","status-publish","format-standard","has-post-thumbnail","hentry"],"meta_box":{"mail":"Coordonator: conf.univ.dr. Adela Nechifor-Boil\u0103 (adela.nechifor-boila@umfst.ro)Laborant: Solov\u0103stru Lorena-Andreea (lorena.solov\u0103stru@umfst.ro)","telefon":"0265-208942 int. 475","adresa_centru":"Laboratorul de Morfologie Normal\u0103 \u0219i Patologic\u0103, Centrul Avansat de Cercet\u0103ri Medicale \u0219i Farmaceutice, Universitatea de Medicin\u0103, Farmacie, \u0218tiin\u021be \u0219i Tehnologie \u201cGeorge Emil Palade\u201d din T\u00e2rgu Mure\u0219, Strada Gheorghe Marinescu nr.38, 540142, T\u00e2rgu Mure\u0219, Rom\u00e2nia.","facebook":"","website_centru":"","echipa":"

Conf.univ.dr. Adela NECHIFOR-BOIL\u0102 (adela.nechifor-boila@umfst.ro<\/a>)<\/p>\n

Prof. univ. dr. \u00a0Angela BORDA (angela.borda@umfst.ro<\/a>)<\/p>\n

\u0218ef lucr\u0103ri dr. Laura CHINEZU (laura.chinezu@umfst.ro<\/a>)<\/p>\n

Prof. univ. dr. Andrada LOGHIN (andrada.loghin@umfst.ro<\/a>)<\/p>\n

Asist. univ. dr. Emoke SZASZ (emoke.szasz@umfst.ro<\/a>)<\/p>\n

Laborant Lorena SOLOV\u0102STRU (lorena.solovastru@umfst.ro<\/a>)<\/p>\n

Tehnician Dorina CIURC\u0102 (dorina.ciurca@umfst.ro<\/a>)<\/u><\/p>\n

Tehnician Valeria MESARO\u0218 (valeria.mesaros@umfst.ro<\/a>)<\/u><\/p>\n","servicii":"

Histoprocesarea \u021besuturilor \u0219i servicii histologice de baz\u0103 <\/strong>(prelevarea \u021besutului; fixarea, deshidratarea, clarificarea \u0219i impregnarea \u00een parafin\u0103 a \u021besutului; \u00a0includerea \u00een parafin\u0103 a probelor; sec\u021bionarea blocurilor de parafin\u0103; colorarea uzual\u0103 cu hematoxilin\u0103-eozin\u0103; efectuarea de colora\u021bii speciale; montarea lamelor).<\/p>\n

Sec\u021bionarea \u021besuturilor la ghea\u021b\u0103.<\/strong><\/p>\n

Efectuarea reac\u021biilor de imunohistochimie, imunofluorescen\u021b\u0103, hibridizare in situ.<\/strong><\/p>\n

Achizi\u021bia de imagini ale preparatelor microscopice.<\/strong><\/p>\n

Izolarea \u0219i microdisec\u021bia laser a celulelor\/grupurilor de celule specifice.<\/strong><\/p>\n

Scanarea \u0219i achizi\u021bia de imagini de rezolu\u021bie \u00eenalt\u0103 a lamelor histologice.<\/strong><\/p>\n

Evaluarea morfologic\u0103 \u0219i expertiz\u0103 \u00een interpretarea lamelor.<\/strong><\/p>\n

Consultan\u021b\u0103 \u00een depunerea \u0219i realizarea proiectelor de cercetare care includ component\u0103 de morfologie.<\/strong><\/p>\n","activitati_de_cercetare":"

    \n
  1. Conducte valvulate cu diametrul redus tip RVOT cu capacitate regenerativ\u0103 pentru pacien\u021bii pediatrici<\/strong>, director de proiect Prof. Dr. Dan Simionescu, suma finan\u021bat\u0103 599.901 RON, perioada de derulare 5.11.2020-22.10.2022.<\/li>\n
  2. Evaluarea efectului anti-tumoral al matricii biologice derivate din \u021besutul adipos \u00eenc\u0103rcat cu medicamentele chimioterapeutice<\/strong>, director de proiect Prof. Dr. Giulio Alessandri, suma finan\u021bat\u0103 599.748 RON, , perioada de derulare: 5.11.2020-22.10.2022.<\/li>\n
  3. Clusterina, un nou agent terapeutic util \u00een clearance-ul amiloidului vascular<\/strong>, director de proiect prof. dr. C\u0103rare Roxana, suma finan\u021bat\u0103 1.198.251 RON, perioada de derulare 05.03.2021-31.12.2023.<\/li>\n
  4. Reducerea neuroinflama\u021biei \u0219i afect\u0103rii cognitive induse de A\u03b2 pe un model de \u0219oricel tip APP\/PS1 av\u00e2nd ca \u0219i \u021bint\u0103 protein kinaza 2 activat\u0103 de MAPK<\/strong>, director de proiect prof.univ.dr. Mark Anthony Slevin, suma finan\u021bat\u0103 599.536 RON, perioada de derulare 21.06.2022-20.06.2024.<\/li>\n
  5. Celulele intramurale ca biomarkeri \u0219i \u021binte terapeutice pentru boala Alzheimer<\/strong>, director de proiect prof. dr. Roxana C\u0103rare, suma finan\u021bat\u0103 7.000.000 RON, perioada de derulare 01.07.2023-30.06.2026.<\/li>\n
  6. Rolul variantelor proteinei matriceale HIV-1 p17 \u00een limfomagenez\u0103: dezvoltarea de noi instrumente diagnostice \u0219i abord\u0103ri terapeutice<\/strong>, director de proiect dr. Francesca Caccuri, suma finan\u021bat\u0103 6.000.000 RON, perioada de derulare 01.01.2024-30.06.2026.<\/li>\n
  7. NeuroX \u2013 \u00cenfiin\u021barea Centrului Rom\u00e2n de Excelen\u021b\u0103 \u00een Neuro\u0219tiin\u021be<\/strong>, director de proiect prof.univ.dr. Roxana C\u0103rare, suma finan\u021bat\u0103 85.900.000 RON.<\/li>\n
  8. \u021aintirea unei noi c\u0103i fibrotice pentru a \u00eembun\u0103t\u0103\u021bi predic\u021bia \u0219i tratamentul \u00een insuficien\u021ba cardiac\u0103, <\/strong>director de proiect dr. Alina Scridon, proiect UEFISCDI, <\/strong>PN-IV-P8-8.3-ROMD-2023-0007, perioada de derulare 20.05.2024-19.05.2026<\/li>\n
  9. Impactul moleculelor imunosupresive PDL-1 \u0219i Siglec-15 asupra TILs asociat oncogenezei gastrice, <\/strong>director de proiect dr. Cozac-Sz\u0151ke Andreea-Raluca, 2024-2025, Grant Intern de Cercetare \u0218tiin\u021bific\u0103 Individual\u0103 UMFST nr. 171\/11\/09.01.2024, suma finan\u021bat\u0103 25000 RON.<\/li>\n
  10. Utilizarea inteligen\u021bei artificiale \u00een determinarea expresiei imunohistochimice a PD-L1 (Programmed Death Ligand 1) \u00een carcinoamele uroteliale ale vezicii urinare utiliz\u00e2nd clona 73-10, prin compara\u021bie cu SP263<\/strong>, director de proiect dr. Nechifor-Boil\u0103 Alin, Grant Intern de Cercetare \u0218tiin\u021bific\u0103 Individual\u0103 UMFST nr. 164\/22\/10.01.2023, perioada de derulare 10.01.2023-10.01.2024.<\/li>\n
  11. Determinarea valorii prognostice a imunomarcajului SDHB \u00een stratificarea riscului de metastazare la pacien\u021bii cu feocromocitoame,<\/strong> director de proiect Dr. Ramona C\u0103tan\u0103, suma finan\u021bat\u0103 25.000 RON, perioada de implementare a grantului: 01.2023-01.2024.<\/li>\n
  12. Comutatori metabolici \u00eentre lipoliz\u0103 \u0219i glicoliz\u0103 \u2013 evaluarea influen\u021bei asupra stresului oxidativ \u00een dou\u0103 modele animale distincte,<\/strong> director de proiect dr. Pu\u0219ca\u0219 (Miklos) Amalia, suma finan\u021bat\u0103 24.627 RON, perioada de implementare a grantului: 01.2023-01.2024.<\/li>\n
  13. Evaluarea nutri\u021bional\u0103 \u0219i efectele asupra s\u0103n\u0103t\u0103\u021bii a unor alternative proteice sustenabile<\/strong>, director de proiect dr. Filip Cristina, suma finan\u021bat\u0103 24.627 RON, perioada de implementare a grantului: 01.2023-01.2024.<\/li>\n
  14. Caracterizarea morfologic\u0103 \u0219i imunohistochimic\u0103 a modific\u0103rilor vasculare pulmonare \u00een cazurile fatale confirmate cu infec\u021bie COVID-19: studiu bazat pe necropsii medico-legale complete<\/strong>, dr. Laura Chinezu, suma finan\u021bat\u0103 25.000 RON, perioada de implementare a grantului: 01.2022-01.2023.<\/li>\n<\/ol>\n","publicatii_centru":"

    Nechifor-Boil\u0103 IA, Nechifor-Boil\u0103 A, Loghin A, Mihu CM, Melincovici CS, Onofrei MM, Chibelean CB, Martha O, Borda A. Artificial Intelligence (AI) for Programmed Death Ligand-1 (PD-L1) Immunohistochemical Assessment in Urothelial Carcinomas: \"Teaching\" Cell Differentiation to AI Systems. Life (Basel). 2025 May 22;15(6):839. doi: 10.3390\/life15060839. Erratum in: Life (Basel). 2025 Aug 15;15(8):1297. doi: 10.3390\/life15081297. PMID: 40566494; PMCID: PMC12194390.<\/p>\n

    Filip C, \u0218tef\u0103nescu R, \u0150sz BE, Pu\u0219ca\u0219 A, Tanase C, Nechifor-Boil\u0103 A, Tero-Vescan A. Sex-Specific Biochemical and Histopathological Effects of Chronic Meat-Based vs. Plant-Based Burger Consumption in a Rodent Model. Foods. 2025 Mar 5;14(5):888. doi: 10.3390\/foods14050888. PMID: 40077591; PMCID: PMC11898711.<\/p>\n

    Moraru L, Moraru R, Chiorean DM, Void\u0103zan S, Solov\u0103stru L, Mitranovici MI. Histopathological Characteristics of Placenta in Pregnancies Complicated by Intrauterine Growth Restriction-A Pilot Study. Diagnostics (Basel). 2025 Dec 24;16(1):60. doi: 10.3390\/diagnostics16010060. PMID: 41515555; PMCID: PMC12785729.<\/p>\n

    Gliga MC, Chinezu L, Preda C, Rotariu DI, Pascanu MI. Immunohistochemical analysis of filamin a expression in acromegaly and its correlation with tumor characteristics and treatment response. Sci Rep. 2025 Nov 19;15(1):40706. doi: 10.1038\/s41598-025-24398-6. Erratum in: Sci Rep. 2026 Jan 26;16(1):3254. doi: 10.1038\/s41598-026-36974-5. PMID: 41258226; PMCID: PMC12630665.<\/p>\n

    Laslo A, Boghi\u021boiu TG, Chinezu L, Manu D, Dumitru Ivanescu A, Cordo\u0219 BA, Wilson MR, Banescu C, Fryer JD, Verma A, Dewing JM, Carare RO. Intrahippocampally Injected Human Recombinant Clusterin Reduces Amyloid-\u03b2 Aggregate Size in Cerebral Arteriole Walls of Clusterin Knockout Mice. Neuropathol Appl Neurobiol. 2025 Oct;51(5):e70037. doi: 10.1111\/nan.70037. PMID: 40919646; PMCID: PMC12415937.<\/p>\n

    Dewing JM, Keable A, Laslo A, Chinezu L, Ivanescu A, Ratnayaka JA, Kalaria R, Slevin M, Verma A, Carare RO. Proportions of Basement Membrane Proteins in Cerebrovascular Smooth Muscle Cells After Exposure to Hypercapnia and Amyloid Beta. Cells. 2025 Apr 18;14(8):614. doi: 10.3390\/cells14080614. PMID: 40277938; PMCID: PMC12025956.<\/p>\n

    Gliga MC, Chinezu L, Pascanu IM. Predicting Response to Medical Treatment in Acromegaly via Granulation Pattern, Expression of Somatostatin Receptors Type 2 and 5 and E-Cadherin. Int J Mol Sci. 2024 Aug 8;25(16):8663. doi: 10.3390\/ijms25168663. PMID: 39201352; PMCID: PMC11354630.<\/p>\n

    Pastorello Y, Russo AP, B\u0103nescu C, Caprio V, G\u00e1ll Z, Potempa L, Cordo\u0219 B, Di Napoli M, Slevin M. Brain Vascular Expression of Monomeric C-Reactive Protein Is Blocked by C10M Following Intraperitoneal Injection in an ApoE-\/- Murine Model of Dyslipidemia: An Immunohistochemical Analysis. Cureus. 2024 May 20;16(5):e60682. doi: 10.7759\/cureus.60682. PMID: 38899254; PMCID: PMC11186519.<\/p>\n

    Muresan S, Slevin M, Szasz E, Loghin A. Monomeric C-Reactive Protein Potential Utilization in the Histological Assessment of Inflammatory Bowel Disease (IBD) Patients. Cureus. 2024 Jun 26;16(6):e63200. doi: 10.7759\/cureus.63200. PMID: 38938906; PMCID: PMC11210427.<\/p>\n

     <\/p>\n","patente_brevete_de_inventie":""},"_links":{"self":[{"href":"https:\/\/umfst.ro\/hu\/wp-json\/wp\/v2\/centru-ucsdt\/49539","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/umfst.ro\/hu\/wp-json\/wp\/v2\/centru-ucsdt"}],"about":[{"href":"https:\/\/umfst.ro\/hu\/wp-json\/wp\/v2\/types\/centru-ucsdt"}],"author":[{"embeddable":true,"href":"https:\/\/umfst.ro\/hu\/wp-json\/wp\/v2\/users\/25"}],"replies":[{"embeddable":true,"href":"https:\/\/umfst.ro\/hu\/wp-json\/wp\/v2\/comments?post=49539"}],"version-history":[{"count":1,"href":"https:\/\/umfst.ro\/hu\/wp-json\/wp\/v2\/centru-ucsdt\/49539\/revisions"}],"predecessor-version":[{"id":50938,"href":"https:\/\/umfst.ro\/hu\/wp-json\/wp\/v2\/centru-ucsdt\/49539\/revisions\/50938"}],"up":[{"embeddable":true,"href":"https:\/\/umfst.ro\/hu\/wp-json\/wp\/v2\/pages\/17078"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/umfst.ro\/hu\/wp-json\/wp\/v2\/media\/43064"}],"wp:attachment":[{"href":"https:\/\/umfst.ro\/hu\/wp-json\/wp\/v2\/media?parent=49539"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}