{"id":18352,"date":"2023-11-15T12:26:44","date_gmt":"2023-11-15T10:26:44","guid":{"rendered":"https:\/\/umfst.ro\/?page_id=18352"},"modified":"2023-11-15T20:18:54","modified_gmt":"2023-11-15T18:18:54","slug":"ipsgenaml","status":"publish","type":"page","link":"https:\/\/umfst.ro\/hu\/universitate\/departament-proiecte-europene\/anunturi\/cercetare\/fonduri-nationale\/uefiscdi\/ipsgenaml\/","title":{"rendered":"IPSGENAML"},"content":{"rendered":"<div data-elementor-type=\"wp-page\" data-elementor-id=\"18352\" class=\"elementor elementor-18352\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-0bba091 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"0bba091\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-1e7cafb\" data-id=\"1e7cafb\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c3250f8 elementor-widget elementor-widget-text-editor\" data-id=\"c3250f8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<header><h2>IPSGENAML &#8211; \u201cDezvoltarea unui scor poligenic integrativ pentru prognosticul pacientilor cu leucemie acuta mieloida folosind abordari genomice complexe\u201d<\/h2><\/header><p><strong>P4 Cercetare fundamentala si de frontiera<\/strong><\/p><p><strong>Proiecte de cercetare exploratorie PCE<\/strong><\/p><p><strong>\u201e<\/strong><strong>Dezvoltarea unui scor poligenic integrativ pentru prognosticul pacientilor cu leucemie acuta mieloida folosind abordari genomice complexe\u201d <\/strong><\/p><p><strong>Cod proiect: PN-III-P4-ID-PCE-2020-1928, numar contract 72\/2021 <\/strong><\/p><p><strong>Acronim <\/strong> <strong>IPSGENAML<\/strong><\/p><p><strong>Perioada de derulare<\/strong> a proiectului: 4.01.2021 &#8211; 31.12.2023<\/p><p>Valoare contract: 1198000,00 lei<\/p><p><strong>Echipa <\/strong><\/p><p>Director proiect<br \/>\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Banescu Claudia &#8211; UMFST GE Palade T\u00e2rgu Mures<\/p><p>Cercetatori<\/p><ul><li>\u00a0Trifa Adrian &#8211; UMF Iuliu Hatieganu Cluj Napoca, Institutul Oncologic Cluj Napoca,<\/li><li>Lazar Erzebet- UMFST GE Palade T\u00e2rgu Mure\u0219<\/li><li>Irina Armean &#8211; bioinformatician la Ensembl Variation, EMBL &#8211; EBI, UK<\/li><\/ul><p>\u00a0<\/p><p>Doctoranzi:<\/p><p>Tripon Florin, Boglis Alina, Crauciuc Andrei, Anciuc Madalina, Moldovan Valeriu &#8211; UMFST GE Palade T\u00e2rgu Mures<\/p><p><strong>Scop<\/strong> stabilirea unei \u201esemnaturi\u201d genomice printr-un model multivariabil care include un scor poligenic integrativ (wIPS) pentru un prognostic cat mai precis printr-o abordare genomica complexa a leucemiei acute mieloide (LAM).<\/p><p><strong>Obiectivul principal<\/strong> este evaluarea semnificatiei prognostice a scorului wIPS bazat pe variante genice, expresie genica, anomalii ale numarului de copii (CNA) la pacientii cu LAM.<\/p><p><strong>Obiectivele specifice sunt<\/strong>: dezvoltarea unui panel personalizat de secventiere de generatie noua (NGS), si a unui panel pentru expresie genica (in vederea definirii profilului expresiei LAM). Alt obiectiv consta in integrarea datelor obtinute prin NGS, expresie genica cu fuziuni genice si CNA \u00een scorul wIPS. De asemenea datele obtinute vor fi utilizate pentru investigarea corelatiei genelor exprimate diferit cu supravietuirea si dezvoltarea unei \u201esemnaturi\u201d multigenice in LAM; examinarea asocierii dintre variantele genice, expresia genica, profilul clinic, gene de fuziune si aparitia comutatiilor; pentru a stabili impactul prognostic si profilul clinic al mutatiilor noi.<\/p><p><strong>Diseminarea rezultatelor<\/strong><\/p><p><strong>Publicatii<\/strong><\/p><ul><li>Balla B, Tripon F,<strong> Banescu C.<\/strong> From Descriptive to Functional Genomics of Leukemias Focusing on Genome Engineering Techniques. Int J Mol Sci. 2021 Sep 17;22(18):10065. doi: 10.3390\/ijms221810065, articol publicat in revista din zona Q1, factor de impact 5.924.<br \/><a href=\"https:\/\/www.mdpi.com\/1422-0067\/22\/18\/10065\" target=\"_blank\" rel=\"noopener noreferrer\">https:\/\/www.mdpi.com\/1422-0067\/22\/18\/10065 <\/a><\/li><\/ul><ul><li><strong>Banescu<\/strong><strong>\u00a0C<\/strong>, Tripon F, Bojan AS, Trifa AP, Muntean C, Crauciuc GA, Boglis A, Candea M, Lazar E, Jimbu L, Iancu M.\u00a0Association of TLR4 Rs4986791 Polymorphism and TLR9 Haplotypes with Acute Myeloid Leukemia Susceptibility: A Case-Control Study of Adult Patients.\u00a0J Pers Med. 2022 Mar 6;12(3):409. doi: 10.3390\/jpm12030409.\u00a0articol publicat in revista din zona Q1, factor de impact 5.924.<br \/><a href=\"https:\/\/www.mdpi.com\/2075-4426\/12\/3\/409\" target=\"_blank\" rel=\"noopener noreferrer\">https:\/\/www.mdpi.com\/2075-4426\/12\/3\/409<\/a><\/li><\/ul><ul><li>Muntean C, Starcea IM, Stoica C, <strong>Banescu<\/strong><strong>\u00a0C<\/strong>. Clinical Characteristics, Renal Involvement, and Therapeutic Options of Pediatric Patients With Fabry Disease. Front Pediatr. 2022 Jun 1;10:908657. doi: 10.3389\/fped.2022.908657. eCollection 2022.Front Pediatr. 2022 Oct 19;10:1045199. doi: 10.3389\/fped.2022.1045199. eCollection 2022.<br \/><a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2022.1045199\/full\" target=\"_blank\" rel=\"noopener noreferrer\">https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2022.1045199\/full<\/a><\/li><\/ul><ul><li><span lang=\"EN-GB\" style=\"font-size: 11.0pt;line-height: 150%\">B\u0103nescu C, Tripon F, Muntean C. The Genetic Landscape of Myelodysplastic Neoplasm Progression to Acute Myeloid Leukemia. <i>Int J Mol Sci<\/i>. 2023;24(6):5734.<br \/>Published 2023 Mar 17. doi:10.3390\/ijms24065734<\/span><span style=\"font-size: 11.0pt;line-height: 150%\">.<\/span><span lang=\"EN-GB\" style=\"font-size: 11.0pt;line-height: 150%\"> articol publicat<br \/>in revista din zona Q1, factor de impact 5.6. <\/span><span lang=\"EN-GB\"><a href=\"https:\/\/www.mdpi.com\/1422-0067\/24\/6\/5734\" target=\"_blank\" rel=\"noopener\"><span style=\"font-size: 11.0pt;line-height: 150%\"><br \/>https:\/\/www.mdpi.com\/1422-0067\/24\/6\/5734<\/span><\/a><\/span><\/li><li><span lang=\"EN-GB\" style=\"font-size: 11.0pt;line-height: 150%\">Balla B, Tripon F, Candea M, Banescu C. Copy Number Variations and Gene Mutations Identified by Multiplex Ligation-Dependent Probe Amplification in Romanian Chronic Lymphocytic Leukemia Patients. <i>J Pers Med<\/i>. 2023;13(8):1239.<br \/>Published 2023 Aug 9. doi:10.3390\/jpm13081239, <\/span><span lang=\"EN-GB\" style=\"font-size: 11.0pt;line-height: 150%\">articol publicat in revista din zona Q2, factor de impact 3.4.<br \/><\/span><span lang=\"EN-GB\"><a href=\"https:\/\/www.mdpi.com\/2075-4426\/13\/8\/1239\" target=\"_blank\" rel=\"noopener\"><span style=\"font-size: 11.0pt;line-height: 150%\">https:\/\/www.mdpi.com\/2075-4426\/13\/8\/1239<\/span><\/a><\/span><\/li><\/ul><p><strong>\u00a0<\/strong><\/p><p><strong>Prezentari la manifestari stiintifice<\/strong><\/p><ul><li>\u201eTestarea genetica in prognosticul si terapia personalizata in mieloprofiferari cronice si leucemii acute\u201d Banescu C (sub forma de prezentare orala) A V-a Conferinta multidisciplinara, 16-18 decembrie 2021, Tg Mures, <a href=\"https:\/\/conferintamultidisciplinara.ro\/\" target=\"_blank\" rel=\"noopener noreferrer\"><br \/>https:\/\/conferintamultidisciplinara.ro\/ <\/a><\/li><li>Diagnostice genetice \u2013 Actualitati din diagnosticul molecular cu aplicabilitate in practica clinica. Florin Tripon (prezentare orala) A V-a Conferinta multidisciplinara, 16-18 decembrie 2021, Tg Mures,<br \/><a href=\"https:\/\/conferintamultidisciplinara.ro\/\" target=\"_blank\" rel=\"noopener noreferrer\"> https:\/\/conferintamultidisciplinara.ro\/ <\/a><\/li><li>Participarea cu lucrarea intitulata The spectrum of genetic mutations in acute myeloid leukemia progression from myelodysplastic syndrome &#8211; Claudia B\u0103nescu, Andrei Crauciuc, Alina Bogli\u0219, Florin Tripon, Al VI-lea Congres de Genetic\u0103 Medical\u0103 cu participare interna\u0163ional\u0103, Craiova 22-25 septembrie 2022,<br \/><a href=\"http:\/\/geneticamedicala.ro\/curs-si-congres-2022\/\" target=\"_blank\" rel=\"noopener noreferrer\">http:\/\/geneticamedicala.ro\/curs-si-congres-2022\/<\/a>\u00a0(prezentare orala)<\/li><li>Participarea cu lucrarea intitulata \u201cLeucemia acut\u0103 mieloid\u0103 \u00een era medicinei de precizie: progrese recente \u00een diagnostic,prognostic, tratament\u201d\u00a0Banescu\u00a0C (prezentare orala) 7-8 Decembrie 2022 la Targu Mures in cadrul\u00a0Zilelor UMFST George Emil Palade 2022, Simpozionul National: \u201e110 ani de la na\u0219terea savantului George Emil Palade, tradi\u021bie \u0219i continuitate in cercetarea medicala rom\u00e2neasc\u0103&#8221;<br \/><a href=\"https:\/\/zilele.umfst.ro\/program-detaliat\/\" target=\"_blank\" rel=\"noopener noreferrer\">https:\/\/zilele.umfst.ro\/program-detaliat\/<\/a><\/li><\/ul><ul><li>Participarea cu lucrarea intitulata \u201cThe influence of different single nucleotide polymorphisms on acute myeloid leukemia\u201d, Tripon Florin, Crauciuc George Andrei, Erzsebet Lazar, Muntean (Duicu Carmen), Trifa Adrian, Alina Boglis, Mihaela Iancu,\u00a0Banescu\u00a0Claudia\u00a0Al VI-lea Congres de Genetic\u0103 Medical\u0103 cu participare interna\u0163ional\u0103, Craiova 22-25 septembrie 2022,<br \/><a href=\"http:\/\/geneticamedicala.ro\/curs-si-congres-2022\/\" target=\"_blank\" rel=\"noopener noreferrer\">http:\/\/geneticamedicala.ro\/curs-si-congres-2022\/<\/a>\u00a0(poster)<\/li><li>Participarea cu lucrarea intitulata \u201cUtility of comprehensive molecular testing of patients with acute myeloid leukemia\u201d Andrei Crauciuc, Florin Tripon, Adrian Trifa, Erzsebet Lazar, Alina Boglis, Claudia B\u0103nescu, Al VI-lea Congres de Genetic\u0103 Medical\u0103 cu participare interna\u0163ional\u0103, Craiova 22-25 septembrie 2022,<br \/><a href=\"http:\/\/geneticamedicala.ro\/curs-si-congres-2022\/\" target=\"_blank\" rel=\"noopener noreferrer\">http:\/\/geneticamedicala.ro\/curs-si-congres-2022\/<\/a>\u00a0(poster)<\/li><li>Impactul unor polimorfisme genetice in leucemia acuta mieloida. Florin Tripon, Adrian Trifa, Erzsebet Lazar, Claudia Banescu. A XII-a Conferin\u021b\u0103 Na\u021bional\u0103 de Genetic\u0103 Medical\u0103, 26-27 februarie 2022, Iasi.<br \/><a href=\"https:\/\/www.srgm.ro\/index.php\/2022\/03\/01\/culegere-rezumate-de-la-a-xii-a-conferinta-nationala-de-genetica-medicala\/\" target=\"_blank\" rel=\"noopener noreferrer\">https:\/\/www.srgm.ro\/index.php\/2022\/03\/01\/culegere-rezumate-de-la-a-xii-a-conferinta-nationala-de-genetica-medicala\/<\/a><\/li><\/ul><ul><li>Participarea cu lucrarea intitulata Updates in risk-stratification in acute myeloid leukemia &#8211; Claudia B\u0103nescu, Andrei Crauciuc, Alina Bogli\u0219, Balla beata, Florin Tripon, A XIII a Conferint\u0103 de Genetic\u0103 Medical\u0103 cu participare interna\u0163ional\u0103, Timi\u0219oara 28-30 septembrie 2023,<br \/><a href=\"http:\/\/www.srgm.ro\/wp-content\/uploads\/2023\/09\/Volum-Rezumate.pdf\" target=\"_blank\" rel=\"noopener\">http:\/\/www.srgm.ro\/wp-content\/uploads\/2023\/09\/Volum-Rezumate.pdf<\/a> (prezentare orala)<\/li><li>\u201cAcute myeloid leukemia \u2013 associations between genetic alterations, clinical, paraclinical data and prognosis\u201d Florin Tripon, George Andrei Crauciuc, Erzsebet Lazar, Carmen Muntean, Adrian Trifa, Claudia Banescu. A XIII a Conferint\u0103 de Genetic\u0103 Medical\u0103 cu participare interna\u0163ional\u0103, Timi\u0219oara 28-30 septembrie 2023,<br \/><a href=\"http:\/\/www.srgm.ro\/wp-content\/uploads\/2023\/09\/Volum-Rezumate.pdf\" target=\"_blank\" rel=\"noopener\">http:\/\/www.srgm.ro\/wp-content\/uploads\/2023\/09\/Volum-Rezumate.pdf<\/a> (poster)<\/li><li>\u201cGenetic variations of CXCL12\/CXCR4 and susceptibility to acute myeloid leukemia\u201d Andrei Crauciuc, Florin Tripon, Adrian Trifa, Erzsebet Lazar, Alina Boglis, Claudia B\u0103nescu, A XIII a Conferint\u0103 de Genetic\u0103 Medical\u0103 cu participare interna\u0163ional\u0103, Timi\u0219oara 28-30 septembrie 2023,<br \/><a href=\"http:\/\/www.srgm.ro\/wp-content\/uploads\/2023\/09\/Volum-Rezumate.pdf\" target=\"_blank\" rel=\"noopener\">http:\/\/www.srgm.ro\/wp-content\/uploads\/2023\/09\/Volum-Rezumate.pdf<\/a> (poster)<\/li><li>\u201cGenetic prognostic and risk factors in chronic lymphocytic leukemia\u201d Beata Balla, Florin Tripon, Claudia Banescu A XIII a Conferint\u0103 de Genetic\u0103 Medical\u0103 cu participare interna\u0163ional\u0103, Timi\u0219oara 28-30 septembrie 2023,<br \/><a href=\"http:\/\/www.srgm.ro\/wp-content\/uploads\/2023\/09\/Volum-Rezumate.pdf\" target=\"_blank\" rel=\"noopener\">http:\/\/www.srgm.ro\/wp-content\/uploads\/2023\/09\/Volum-Rezumate.pdf<\/a> (poster)<\/li><li>\u201eInvestigarea genetic\u0103 a pacien\u021bilor cu leucemie acut\u0103 mieloid\u0103\u201d Florin Tripon, George Andrei Crauciuc, Erzsebet Lazar, Carmen Muntean, Adrian Trifa, Claudia Banescu. Conferin\u021ba Na\u021bional\u0103 a Asocia\u021biei de Medicin\u0103 de Laborator din Rom\u00e2nia, cu participare interna\u021bional\u0103, Timi\u0219oara, 14-16 iunie 2023. <a href=\"https:\/\/www.rrml.ro\/articole\/2023\/2023_2_supliment.pdf\" target=\"_blank\" rel=\"noopener\"><br \/>https:\/\/www.rrml.ro\/articole\/2023\/2023_2_supliment.pdf<\/a> (poster)<\/li><li>\u201cImproving the acute myeloid leukemia genome investigation by next generation sequencing\u201d Tripon Florin, Andrei Crauciuc, Boglis Alina, Madalina Anciuc Crauciuc, Erzsebert Lazar Benedek, Iulia Armean, Mihaela Iancu, Pavel Adrian Trifa, Claudia Banescu, Claudia Banescu, Sesiunea \u0219tiin\u021bific\u0103 a cadrelor didactice din cadrul Zilelor\u00a0UMFST G.E. Palade Tg. Mures, 14-15 decembrie, 2023 (prezentare orala)<\/li><li>\u201cGenetic investigation a useful tool for risk stratification of acute myeloid leukemia\u201d Banescu Claudia, Andrei Crauciuc, Alina Boglis, Beata Balla, Florin Tripon Sesiunea \u0219tiin\u021bific\u0103 a cadrelor didactice din cadrul Zilelor\u00a0\u00a0UMFST G.E. Palade Tg. Mures, 14-15 decembrie, 2023 (prezentare orala)<\/li><li>\u201eGenetic factors with prognostic implications in the context of chronic lymphocytic leukemia\u201d Balla Beata, Andrei Crauciuc, Florin Tripon, Claudia Banescu, Sesiunea \u0219tiin\u021bific\u0103 a cadrelor didactice din cadrul Zilelor\u00a0 UMFST G.E. Palade Tg. Mures, 14-15 decembrie, 2023 (prezentare orala)<\/li><\/ul><p><strong>\u00a0<\/strong><\/p><p><strong>Instruire<\/strong><\/p><ul><li>Membrii echipei proiectului (Banescu Claudia, Alina Boglis, Andrei Crauciuc, Florin Tripon) au participat cursul practice de genetica moleculara. \u2013 Tehnici avansate de genetica moleculara, care a avut loc la Craiova, in perioada 19-21 septembrie 2022, <a href=\"http:\/\/geneticamedicala.ro\/curs-si-congres-2022\/\" target=\"_blank\" rel=\"noopener noreferrer\">http:\/\/geneticamedicala.ro\/curs-si-congres-2022\/<\/a><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>IPSGENAML &#8211; \u201cDezvoltarea unui scor poligenic integrativ pentru prognosticul pacientilor cu leucemie acuta mieloida folosind abordari genomice complexe\u201d P4 Cercetare fundamentala si de frontiera Proiecte de cercetare exploratorie PCE \u201eDezvoltarea unui scor poligenic integrativ pentru prognosticul pacientilor cu leucemie acuta mieloida folosind abordari genomice complexe\u201d Cod proiect: PN-III-P4-ID-PCE-2020-1928, numar contract 72\/2021 Acronim IPSGENAML Perioada de [&hellip;]<\/p>\n","protected":false},"author":25,"featured_media":0,"parent":17406,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"2391,13292,17398,6273,2383,12070","_relevanssi_noindex_reason":"","footnotes":""},"categories":[16],"tags":[],"class_list":["post-18352","page","type-page","status-publish","hentry","category-pagina-sidebar"],"meta_box":[],"_links":{"self":[{"href":"https:\/\/umfst.ro\/hu\/wp-json\/wp\/v2\/pages\/18352","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/umfst.ro\/hu\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/umfst.ro\/hu\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/umfst.ro\/hu\/wp-json\/wp\/v2\/users\/25"}],"replies":[{"embeddable":true,"href":"https:\/\/umfst.ro\/hu\/wp-json\/wp\/v2\/comments?post=18352"}],"version-history":[{"count":0,"href":"https:\/\/umfst.ro\/hu\/wp-json\/wp\/v2\/pages\/18352\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/umfst.ro\/hu\/wp-json\/wp\/v2\/pages\/17406"}],"wp:attachment":[{"href":"https:\/\/umfst.ro\/hu\/wp-json\/wp\/v2\/media?parent=18352"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/umfst.ro\/hu\/wp-json\/wp\/v2\/categories?post=18352"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/umfst.ro\/hu\/wp-json\/wp\/v2\/tags?post=18352"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}