{"id":35074,"date":"2024-11-14T10:58:53","date_gmt":"2024-11-14T08:58:53","guid":{"rendered":"https:\/\/umfst.ro\/?post_type=proiect-european&p=35074"},"modified":"2024-11-14T10:58:53","modified_gmt":"2024-11-14T08:58:53","slug":"tintirea-unei-noi-cai-fibrotice-pentru-a-imbunatati-predictia-si-tratamentul-in-insuficienta-cardiaca","status":"publish","type":"proiect-european","link":"https:\/\/umfst.ro\/hu\/universitate\/departament-proiecte-europene\/proiect-european\/tintirea-unei-noi-cai-fibrotice-pentru-a-imbunatati-predictia-si-tratamentul-in-insuficienta-cardiaca\/","title":{"rendered":"\u021aintirea unei noi c\u0103i fibrotice pentru a \u00eembun\u0103t\u0103\u021bi predic\u021bia \u0219i tratamentul \u00een insuficien\u021ba cardiac\u0103"},"content":{"rendered":"

Obiectivul proiectului: Scopurile noastre majore sunt de a elucida rolul S1P-S1P3 \u00een IC \u0219i de a dezvolta o terapie nou\u0103, bazat\u0103 pe blocarea S1P3, pentru a atenua remodelarea cardiac\u0103 \u0219i IC.
Obiectivele proiectului sunt: (1) Investigarea bloc\u0103rii S1P3 ca poten\u021bial\u0103 terapie nou\u0103 pentru IC \u2013 Vom evalua dac\u0103 inhibarea S1P3 atenueaz\u0103 inflama\u021bia \u0219i fibroza cardiac\u0103 \u0219i amelioreaz\u0103 IC \u00een dou\u0103 modele in vivo la \u0219obolan, precum \u0219i in vitro. (2) Explorarea contribu\u021biei c\u0103ilor asociate S1P-S1P3 \u00een patogeneza IC \u2013 Vom folosi o combina\u021bie de studii transcriptomice, histologice \u0219i de expresie proteic\u0103 pentru a investiga rolul S1P-S1P3 \u00een remodelarea cardiac\u0103 \u0219i \u00een IC \u00een dou\u0103 modele experimentale. Rezultatele vor fi validate \u00een miocardul uman. (3) Investigarea S1P ca biomarker predictiv de evenimente cardiovasculare majore \u0219i de r\u0103spuns la terapia de resincronizare cardiac\u0103 la pacien\u021bii cu IC.<\/p>","protected":false},"excerpt":{"rendered":"

Proiect de colaborare cu Republica Moldova finantat de UEFISCDI<\/p>","protected":false},"featured_media":34960,"template":"","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"17954,25110,27427,20602,23138,14337","_relevanssi_noindex_reason":"","footnotes":""},"sursa-finantare":[251],"class_list":["post-35074","proiect-european","type-proiect-european","status-publish","has-post-thumbnail","hentry","sursa-finantare-fonduri-nationale"],"meta_box":{"domeniu":"\u0219tiin\u021bele vietii","valoare_proiect":"715.648,00 lei","director_de_proiect":"Prof. dr. Alina Scridon","perioada_de_implementare":"20.05.2024 -19.05.2026","website":""},"_links":{"self":[{"href":"https:\/\/umfst.ro\/hu\/wp-json\/wp\/v2\/proiect-european\/35074","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/umfst.ro\/hu\/wp-json\/wp\/v2\/proiect-european"}],"about":[{"href":"https:\/\/umfst.ro\/hu\/wp-json\/wp\/v2\/types\/proiect-european"}],"version-history":[{"count":0,"href":"https:\/\/umfst.ro\/hu\/wp-json\/wp\/v2\/proiect-european\/35074\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/umfst.ro\/hu\/wp-json\/wp\/v2\/media\/34960"}],"wp:attachment":[{"href":"https:\/\/umfst.ro\/hu\/wp-json\/wp\/v2\/media?parent=35074"}],"wp:term":[{"taxonomy":"sursa-finantare","embeddable":true,"href":"https:\/\/umfst.ro\/hu\/wp-json\/wp\/v2\/sursa-finantare?post=35074"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}