Internationalization is a strategic pillar of G.E. Palade UMPhST Targu Mures, having a crucial role in its continuous development. The concept of "Smart Internationalization" adopted by the university is part of its innovative vision, aiming to strengthen its academic and research relevance at European and international level.

G.E. Palade UMPhST Targu Mures capitalizes internationally its strengths by:

• International academic cooperation – academic partnerships with more than 200 universities and research institutions around the world, as well as affiliation to numerous international organizations, which provide opportunities for collaboration and integration into global academic networks;
• International mobilities - through programs such as Erasmus+ (the largest budget in Romania in 2024), Leonardo da Vinci, CEEPUS, etc. over 1000 students and a significant number of teachers enrich their academic and professional experience annually at universities and organizations abroad, also promoting intercultural exchanges;
• Study programs in foreign languages, especially in English, with a preponderance in medical education – more than 1400 international students from over 80 countries study in an interconnected and dynamic community;
• Participation in academic and research projects – through funding attracted of approx. EUR 100 million, contributing to the advancement of knowledge and development of innovative solutions for various global problems in medicine, technologies or entrepreneurship;
• The UMFST – UMCH Branch opened in Hamburg, Germany in 2019, through which the university, the first in Romania to open a branch abroad, brought to Europe a model of academic excellence in terms of medical education;
• Academic and scientific events of international prestige.

The university's internationalization policy and specific activities are implemented by the Department of International Relations, under the coordination of Vice-Rector Office for International Relations, University Networks and Public Relations