Laboratorul de Biologie Moleculară – Genetică – Genomică (BIOMOL)

Cercetare

Prezentare

Laboratorul BIOMOL coordonat de Prof. dr. Claudia Bănescu reunește o echipă dedicată de specialiști în biologie moleculară și genetică medicală, incluzând cercetători, doctoranzi, biologi și asistenți de laborator și tehnicieni. Laboratorul oferă servicii în domeniul biologiei moleculare, precum secvențiere Sanger și secvențiere de nouă generație (NGS), genotipare, analiza expresiei genice, analiza de fragmente și izolarea acizilor nucleici. Misiunea echipei este de a susține atât activitatea de cercetare, cât și nevoile clinice, prin furnizarea unor soluții de testare genetică fiabile și precise. Prin expertiza acumulată și utilizarea tehnologiilor avansate, laboratorul contribuie activ la dezvoltarea domeniului geneticii și biologiei moleculare, sprijinind comunitatea academică.

Coordonator: Prof. dr. Claudia Bănescu

Cercetători: dr. Andrei Crauciuc, dr. Florin Tripon

Personal tehnic: biolog Claudia Cârstea, PhD; asistent de laborator Mihaela Tătar;

Doctoranzi

 

  • Izolarea ADN și ARN din diverse tipuri de probe biologice
  • Secvențiere Sanger și secvențiere de nouă generație (NGS)
  • Genotipare și analiza mutațiilor
  • Analiza expresiei genice (prin metode bazate pe qPCR)
  • Analiză de fragmente, MLPA, etc
  • Dezvoltarea și optimizarea protocoalelor de diagnostic molecular

Cercetarea desfășurată în cadrul Laboratorului BIOMOL utilizează o infrastructură avansată în biologie moleculară, genetică medicală și genomică, având ca scop investigarea mecanismelor moleculare implicate în patologia umană și susținerea dezvoltării abordărilor de medicină personalizată.

Laboratorul se concentrează pe analiza variantelor genetice și genomice și a impactului funcțional al acestora într-o gamă largă de patologii, inclusiv hemopatii maligne, boli cardiovasculare multifactoriale etc. Activitățile de cercetare integrează tehnici moleculare clasice cu tehnologii genomice de înaltă performanță, în vederea explorării mecanismelor bolilor, identificării de biomarkeri și îmbunătățirii strategiilor de diagnostic și prognostic.

În acest context, cercetarea vizează:

  • identificarea și caracterizarea variantelor genetice (SNP-uri, CNV-uri, mutații somatice) utilizând tehnologii NGS și analize țintite;
  • investigarea mecanismelor moleculare implicate în leucemogeneză și progresia bolii;
  • analiza profilurilor de expresie genică și a mecanismelor de reglare, inclusiv microARN-uri;
  • corelarea datelor genomice cu parametrii clinici, fenotipici și prognostici;
  • dezvoltarea și validarea biomarkerilor moleculari cu rol diagnostic și prognostic;
  • implementarea abordărilor genetice (NGS, secvențiere țintită) în studiul bolilor rare și al dizabilității intelectuale;
  • evaluarea bolii reziduale măsurabile (MRD) prin tehnici moleculare;
  • integrarea datelor multi-omice în vederea susținerii strategiilor de medicină personalizată.

Totodată, laboratorul contribuie la dezvoltarea de protocoale standardizate pentru analize moleculare și genomice, facilitând reproductibilitatea și transferul rezultatelor în practica clinică. Rezultatele cercetării contribuie la îmbunătățirea acurateței diagnostice, stratificării riscului și optimizării deciziilor terapeutice.

Laboratorul BIOMOL este activ implicat în proiecte de cercetare, contribuind la dezvoltarea medicinei genomice și la integrarea rezultatelor științifice în sistemele de sănătate.

 

Proiecte de cercetare (selecție):

 

  • Dezvoltarea cercetării genomice în România (ROGEN) – coordonator UMF Carol Davila Bucuresti, Cod Proiect: 324809, Sursă de finanțare: Fondul European de Dezvoltare Regională, Program: Programul Sănătate Cod apel: PS/272/PS_P5/OP1/RSO1.1/PS_P5_RSO1.1_A9
  • FOCUS: Formare și orientare pentru cercetătorii UMFST din domeniul sănătății, Cod proiect:350717, Cofinanțat de: Uniunea Europeană, Programul Sănătate, PS/688/PS_P3/OP4/ESO4.7/PS_P3_ESO4.7_A6, 2025–2029, Buget: 49,291,825.14 RON
  • NeuRoX – „Înființarea Centrului de Excelență din România în Neuroștiințe Clinice”, Cod proiect: PN-IV-P6-6.1-CoEx-2024-0141, Program: Programul 5.6 – Provocări, Subprogram: 5.6.1 – Parteneriate pentru Agenda Strategică, Apel: Centre de Excelență – CoEx, 2026–2030, Buget: 85,900,000 RON
  • Rolul variantelor proteinei matriceale p17 a HIV-1 în limfomageneză: dezvoltarea de noi instrumente de diagnostic și abordări terapeutice, coordonator Francesca Cacurri, valoare 1.137.453,69 euro (finanțat prin Planul Național de Redresare și Reziliență al României, Pilonul III, C8, I.9), CF 12/26.07.2023
  • Celulele intramurale ca biomarkeri și ținte terapeutice în boala Alzheimer, director Roxana Carare, CF63/14.11.2022, PNRR/2022/C9/MCID/I8, valoare 1,4 milioane euro
  • Dezvoltarea unui scor poligenic integrativ pentru prognosticul pacienților cu leucemie acută mieloidă utilizând abordări genomice complexe,PN-III-P4-ID-PCE-2020-1928, 250.000 Euro UEFISCDI
  • Metodă rapidă multiplex de high-resolution melting pentru analiza mutațiilor genelor FLT3, NPM1 și DNMT3A în leucemia acută mieloidă , Cod: PN-III-P2-2.1-PED-2016-1076, contract nr. 147PED/2017, valoare 133.153 euro, finanțat de UEFISCDI
  • Evaluarea efectului combinat al mai multor polimorfisme în vederea definirii predispoziției genetice pentru neoplazii mieloproliferative, PN-III-P1-1.1-PD-2016-1414
  • Identificarea unui panel de microARN-uri pentru diagnosticul și predicția fibrilației atriale. Studiu clinic la pacienți supuși bypass-ului aortocoronarian, PN-III-P1-1.1-PD-2019-0181
  • Secvențierea de nouă generație – un instrument valoros pentru evaluarea impactului mutațiilor somatice suplimentare la pacienții tineri cu neoplazii mieloproliferative non-BCR-ABL, PN-III-P1-1.1-TE2019-1603
  • Dezvoltarea unui ghid diagnostic inovator pentru copilul obez prin evaluare genetică, antropometrică, bioimpedanță și ecografie, Program 4 – Cercetare fundamentală și de frontieră, PN-III-P4-ID-PCE-2016-0766, valoare 250.000 euro
  • Proiecte pentru echipe tinere de cercetare: Identificarea unui panel de microARN-uri asociate genei Pitx2 pentru diagnosticul fibrilației atriale și predicția apariției acesteia, contract 47/2018, PN III-P 1.1.1-TE 2016-0382
  • Blocarea curentului inward activat de hiperpolarizare (If) – o nouă abordare terapeutică în fibrilația atrială izolată, PN-II-RU-TE-2014-4-1544, contract nr. 201/01.10.2015. Agenție de finanțare: UEFISCDI. Buget: 125.000 euro

 

Transfer tehnologic

Pe lângă serviciile de rutină și activitățile de cercetare, Laboratorul BIOMOL contribuie activ la transferul tehnologic, facilitând transpunerea rezultatelor cercetării în practica clinică. Acest proces include:

  • implementarea tehnologiilor genomice avansate (platforme NGS, PCR în timp real, MLPA) în fluxurile de diagnostic;
  • Stoian M, Azamfirei L, Bandila SR, Stoian A, Babă DF, Bănescu C. Circulating microRNAs and Plasma Gelsolin as Biomarkers of Sepsis: Molecular Insights and Prospects for Precision Medicine. 2025;15(11):1621, doi: 10.3390/biom15111621. https://pubmed.ncbi.nlm.nih.gov/41301539/
  • Anciuc-Crauciuc M, Crauciuc GA, Tripon F, Simon M, Cucerea MC, Bănescu CV. Exploring IL-10and NOS3 Genetic Variants as a Risk Factor for Neonatal Respiratory Distress Syndrome and Its Outcome. Diagnostics (Basel). 2025 Sep 6;15(17):2259. doi: 10.3390/diagnostics15172259. https://pubmed.ncbi.nlm.nih.gov/40941746/
  • Anciuc-Crauciuc M, Cucerea MC, Tripon F, Crauciuc GA, Bănescu CV.Descriptive and Functional Genomics in Neonatal Respiratory Distress Syndrome: From Lung Development to Targeted Therapies. Int J Mol Sci. 2024, 25(1):649. doi: 10.3390/ijms25010649. https://pubmed.ncbi.nlm.nih.gov/38203821/
  • Stoian A, Bajko Z, Bălașa R, Andone S, Stoian M, Ormenișan I, Muntean C, Bănescu C. Characteristics of Developmental and Epileptic Encephalopathy Associated with PACS2 p.Glu209Lys Pathogenic Variant-Our Experience and Systematic Review of the Literature. Biomolecules. 2024 Feb 23;14(3):270. doi: 10.3390/biom14030270. https://pubmed.ncbi.nlm.nih.gov/38540691/
  • Ognean ML, Anciuc-Crauciuc M, Galiș R, Stepan AE, Stepan MD, Bănescu C, Grosu F, Kramer BW, Cucerea M. ABCA3 c.838C>T (p.Arg280Cys, R280C) and c.697C>T (p.Gln233Ter, Q233X, Q233*) as Causative Variants for RDS: A Family Case Study and Literature Review. Biomedicines. 2024 Oct 18;12(10):2390. doi: 10.3390/biomedicines12102390. https://pubmed.ncbi.nlm.nih.gov/39457702/
  • Anciuc-Crauciuc M, Cucerea MC, Crauciuc GA, Tripon F, Bănescu CV. Evaluation of the Copy Number Variants and Single-Nucleotide Polymorphisms of ABCA3 in Newborns with Respiratory Distress Syndrome-A Pilot Study. Medicina (Kaunas). 2024 Feb 29;60(3):419. doi: 10.3390/medicina60030419. https://pubmed.ncbi.nlm.nih.gov/38541145/
  • Crișan AS, Tripon F, Bogliș A, Crauciuc GA, Trifa AP, Lázár E, Macarie I, Gabor MR, Bănescu C. The Role of DNA Repair (XPC, XPD, XPF, and XPG) Gene Polymorphisms in the Development of Myeloproliferative Neoplasms. Medicina (Kaunas). 2024 Mar 19;60(3):506. doi: 10.3390/medicina60030506. https://pubmed.ncbi.nlm.nih.gov/38541232/
  • Pastorello Y, Russo AP, Bănescu C, Caprio V, Gáll Z, Potempa L, Cordoș B, Di Napoli M, Slevin M. Brain Vascular Expression of Monomeric C-Reactive Protein Is Blocked by C10M Following Intraperitoneal Injection in an ApoE-/- Murine Model of Dyslipidemia: An Immunohistochemical Analysis. Cureus. 2024 May 20;16(5):e60682. doi: 10.7759/cureus.60682. eCollection 2024 May. https://pubmed.ncbi.nlm.nih.gov/38899254/
  • Onisor D, Brusnic O, Banescu C, Carstea C, Sasaran M, Stoian M, Avram C, Boicean A, Boeriu A, Dobru D. miR-155 and miR-21 as Diagnostic and Therapeutic Biomarkers for Ulcerative Colitis: There Is Still a Long Way to Go. Biomedicines. 2024 Jun 13;12(6):1315. doi: 10.3390/biomedicines12061315. https://pubmed.ncbi.nlm.nih.gov/38927522/
  • Pastorello Y, Manu D, Sawkulycz X, Caprio V, Banescu C, Dobreanu M, Potempa L, Di Napoli M, Slevin M. mCRP-Induced Focal Adhesion Kinase-Dependent Monocyte Aggregation and M1 Polarization, Which Was Partially Blocked by the C10M Inhibitor. Int J Mol Sci. 2024 Mar 7;25(6):3097. doi: 10.3390/ijms25063097. https://pubmed.ncbi.nlm.nih.gov/38542070/
  • Balla B, Tripon F, Lazar E, Bănescu C. Analysis of Mutational Status of IGHV, and Cytokine Polymorphisms as Prognostic Factors in Chronic Lymphocytic Leukemia: The Romanian Experience. Int J Mol Sci. 2024;25(3):1799. doi: 10.3390/ijms25031799. https://pubmed.ncbi.nlm.nih.gov/38339076/
  • Mănescu IB, Gabor MR, Moldovan GV, Hadadi L, Huțanu A, Bănescu C, Dobreanu M. An 8-SNP LDL Cholesterol Polygenic Score: Associations with Cardiovascular Risk Traits, Familial Hypercholesterolemia Phenotype, and Premature Coronary Heart Disease in Central Romania. Int J Mol Sci. 2024 Sep 18;25(18):10038. doi: 10.3390/ijms251810038. https://pubmed.ncbi.nlm.nih.gov/39337524/
  • Bănescu C, Tripon F, Muntean C. The Genetic Landscape of Myelodysplastic Neoplasm Progression to Acute Myeloid Leukemia. Int J Mol Sci. 2023 Mar 17;24(6):5734. doi: 10.3390/ijms24065734. PMID: 36982819. Review. https://pubmed.ncbi.nlm.nih.gov/36982819/
  • Muntean C, Chirtes C, Baczoni B, Banescu C. PAX2 Gene Mutation in Pediatric Renal Disorders-A Narrative Review. Int J Mol Sci. 2023 Aug 13;24(16):12737. doi: 10.3390/ijms241612737. https://pubmed.ncbi.nlm.nih.gov/37628926/
  • Balla B, Tripon F, Candea M, Banescu C. Copy Number Variations and Gene Mutations Identified by Multiplex Ligation-Dependent Probe Amplification in Romanian Chronic Lymphocytic Leukemia Patients. J Pers Med. 2023;13(8):1239. doi: 10.3390/jpm13081239. https://pubmed.ncbi.nlm.nih.gov/37623489/
  • Făgărășan A, Săsăran M, Gozar L, Crauciuc A, Bănescu C. The Role of Galectin-3 in Predicting Congenital Heart Disease Outcome: A Review of the Literature. Int J Mol Sci. 2023 22;24(13):10511. doi: 10.3390/ijms241310511. Review. https://pubmed.ncbi.nlm.nih.gov/37445687/
  • Săsăran MO, Bănescu C. Role of salivary miRNAs in the diagnosis of gastrointestinal disorders: a mini-review of available evidence. Front Genet. 2023;14:1228482. doi: 10.3389/fgene.2023.1228482. Review. https://pubmed.ncbi.nlm.nih.gov/37456668/
  • Chirteș C, Bogliș A, Toth A, Rac C, Bănescu C. Compound heterozygous FAM20C gene variants in a patient with severe Raine syndrome: a case report. Front Genet. 2023 Apr 26;14:1179163. doi: 10.3389/fgene.2023.1179163. https://pubmed.ncbi.nlm.nih.gov/37158450/
  • Banescu C, Tripon F, Bojan AS, et al. Association of TLR4 Rs4986791 Polymorphism and TLR9 Haplotypes with Acute Myeloid Leukemia Susceptibility: A Case-Control Study of Adult Patients. J Pers Med. 2022;12(3):409. https://pubmed.ncbi.nlm.nih.gov/35330409/
  • Muntean C, Starcea IM, Banescu C. Diabetic kidney disease in pediatric patients: A current review. World J Diabetes. 2022;13(8):587-599. doi:10.4239/wjd.v13.i8.587 https://pubmed.ncbi.nlm.nih.gov/36159227/
  • Muntean C, Starcea IM, Stoica C, Banescu C. Clinical Characteristics, Renal Involvement, and Therapeutic Options of Pediatric Patients With Fabry Disease [published correction appears in Front Pediatr. 2022;10:1045199]. Front Pediatr.;10:908657. https://pubmed.ncbi.nlm.nih.gov/35722479/
  • Muntean C, Tripon F, Bogliș A, Bănescu C. Pathogenic Biallelic Mutations in ECHS1 in a Case with Short-Chain Enoyl-CoA Hydratase (SCEH) Deficiency-Case Report and Literature Review. Int J Environ Res Public Health. 2022;19(4):2088. https://pubmed.ncbi.nlm.nih.gov/35206276/
  • Muntean C, Sasaran MO, Crisan A, Banescu C. Effects of PPARG and PPARGC1A gene polymorphisms on obesity markers. Front Public Health. 2022;10:962852. https://pubmed.ncbi.nlm.nih.gov/36466447/
  • Meliț LE, Mărginean CO, Săsăran MO, Mocanu S, Ghiga DV, Crișan A, Bănescu C. Innate Immune Responses in Pediatric Patients with Gastritis-A Trademark of Infection or Chronic Inflammation?. Children (Basel). 2022;9(2):121. https://pubmed.ncbi.nlm.nih.gov/35204842/
  • Tripon F, Bănescu C, Trifa AP, et al. TERT rs2853669 as a predictor for overall survival in patients with acute myeloid leukaemia. Arch Med Sci. 2021;18(1):103-111 https://pubmed.ncbi.nlm.nih.gov/35154531/
  • Bănescu C, Tripon F, Trifa A et al Presence of copy number aberration and clinical prognostic factors in patients with acute myeloid leukemia: an analysis of effect modification. Pol Arch Intern Med 2019;129(12):898-906. doi:10.20452/pamw.15093; IF=2.8 https://pubmed.ncbi.nlm.nih.gov/31808755/
  • Balla B, Tripon F, Banescu C. From Descriptive to Functional Genomics of Leukemias Focusing on Genome Engineering Techniques.Int J Mol Sci. 2021 17;22(18):10065. doi: 10.3390/ijms221810065, (IF=5.923) https://pubmed.ncbi.nlm.nih.gov/34576226/
  • Duicu C, Pitea AM, Săsăran OM, Cozea I, Man L, Bănescu C. Nephrogenic diabetes insipidus in children (Review). Exp Ther Med. 2021 Jul;22(1):746. doi: 10.3892/etm.2021.10178. https://pubmed.ncbi.nlm.nih.gov/34055061/
  • Negovan A, Iancu M, Tripon F, Crauciuc A, Mocan S, Bănescu C. Cytokine TGF-β1, TNF-α, IFN-γand IL-6 Gene Polymorphisms and Localization of Premalignant Gastric Lesions in Immunohistochemically  pylori-negative Patients. Int J Med Sci. 2021;18(12):2743-2751. doi: 10.7150/ijms.60517. https://pubmed.ncbi.nlm.nih.gov/34104107/
  • Negovan A, Szőke AR, Mocan S, Bănescu C. Helicobacter pylori-Positive Gastric Biopsies-Association with Clinical Predictors. Life (Basel). 2022;12(11):1789. doi:10.3390/life12111789, https://pubmed.ncbi.nlm.nih.gov/36362946/
  • Tripon F, Iancu M, Trifa A, Crauciuc GA, Boglis A, Dima D, Lazar E, Bănescu C. Modelling the Effects of MCM7 Variants, Somatic Mutations, and Clinical Features on Acute Myeloid Leukemia Susceptibility and Prognosis. J Clin Med. 2020 Jan 8;9(1):158. doi: 10.3390/jcm9010158. (IF=3,303) https://www.mdpi.com/2077-0383/9/1/158
  • Crauciuc GA, Iancu M, Olah P, Tripon F, …, Bănescu C. Significant Associations between AXIN1 rs1805105, rs12921862, rs370681 Haplotypes and Variant Genotypes of AXIN2 rs2240308 with Risk of Congenital Heart Defects. Int J Environ Res Public Health. 2020, 17(20):7671. doi:10.3390/ijerph17207671. (IF=2,84) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589771/
  • Tripon F, Bogliș A, Micheu C, Streață I, Bănescu C. Pitt-Hopkins Syndrome: Clinical and Molecular Findings of a 5-Year-Old Patient. Genes (Basel). 2020 May 28;11(6):596. doi: 10.3390/genes11060596. (IF=3,759) https://www.mdpi.com/2073-4425/11/6/596
  • Georgescu AM, Banescu C, Azamfirei R, Hutanu A, Moldovan V, Badea I, Voidazan S, Dobreanu M, Chirtes IR, Azamfirei L. Evaluation of TNF-α genetic polymorphisms as predictors for sepsis susceptibility and progression. BMC Infect Dis. 2020 Mar 14;20(1):221. doi: 10.1186/s12879-020-4910-6. (IF=2,688) https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-020-4910-6
  • Lighezan DL, Bojan AS, Iancu M, .., Bănescu C, Trifa AP. TET2 rs1548483 SNP Associating with Susceptibility to Molecularly Annotated Polycythemia Vera and Primary Myelofibrosis. J Pers Med. 2020,10(4):259. doi: 10.3390/jpm10040259. (IF=4,43) https://pubmed.ncbi.nlm.nih.gov/33271790/
  • Tripon F, Iancu M, Trifa A, Crauciuc GA, Boglis A, .., Banescu C. Association Analysis of TP53 rs1042522, MDM2 rs2279744, rs3730485, MDM4 rs4245739 Variants and Acute Myeloid Leukemia Susceptibility, Risk Stratification Scores, and Clinical Features: An Exploratory Study. J Clin Med. 2020;9(6):1672. doi: 10.3390/jcm9061672. (IF=3,303) https://pubmed.ncbi.nlm.nih.gov/32492903/
  • Bogliş A, Cosma AS, Tripon F, Bãnescu C. Exon 21 deletion in the OPHN1 gene in a family with syndromic X-linked intellectual disability: Case report. Medicine (Baltimore). 2020 ;99(33):e21632. doi: 10.1097/MD.0000000000021632. (IF=1,552) https://pubmed.ncbi.nlm.nih.gov/32872024/
  • Tripon F, Iancu M, Trifa A, Crauciuc GA, Boglis A, Dima D, Lazar E, Bănescu C. Modelling the Effects of MCM7 Variants, Somatic Mutations, and Clinical Features on Acute Myeloid Leukemia Susceptibility and Prognosis. J Clin Med. 2020 Jan 8;9(1). pii: E158. doi: 10.3390/jcm9010158. IF=5.688 https://www.mdpi.com/2077-0383/9/1/158
  • Tripon F, Crauciuc GA, Bogliş A, Moldovan V, Sándor-Kéri J, Benedek IJ, Trifa AP, Bănescu C. Co-occurrence of PML-RARA gene fusion, chromosome 8 trisomy, and FLT3 ITD mutation in a young female patient with de novo acute myeloid leukemia and early death: A CARE case report. Medicine (Baltimore). 2020 Apr;99(14):e19730. doi: 10.1097/MD.0000000000019730. (IF=1,552) https://pubmed.ncbi.nlm.nih.gov/32243411/
  • Nechifor-Boilă A, Banescu C, Zahan AE, Moldovan V, Szasz E, Borda A. DNA isolation from achieved formalin-fixed paraffin-embedded tissues in a series of 212 thyroid carcinoma cases: the influence of preanalytical factors on DNA quantity and purity. J Investig Med. 2020 Mar;68(3):792-798. doi: 10.1136/jim-2019-001134. (IF=2,304) https://pubmed.ncbi.nlm.nih.gov/31801793/
  • Trifa AP, Lighezan DL, Jucan C, Tripon F, Arbore DR, Bojan A, Gligor-PopaS, Pop M R, Dima D, Banescu C. SH2B3 (LNK) rs3184504 polymorphism is correlated with JAK2 V617F-positive myeloproliferative neoplasms. Rev Romana Med Lab. 2020;28(3):267-77. DOI:10.2478/rrlm-2020-0025 (IF=0,945), https://www.rrml.ro/articole/2020/2020_3_3.pdf
  • Vasilache SL, Mărginean CO, Boaghi A, Pop RM, Banescu C, et al. Implications of visfatin genetic variants in the metabolic profile of the Romanian pediatric population. Rev Romana Med Lab. 2020;28(2):163-74. DOI:10.2478/rrlm-2020-0015, https://www.rrml.ro/articole/2020/2020_2_5.pdf
  • Bănescu C, Tripon F, Trifa AP, Crauciuc AG, et al. Cytokine rs361525, rs1800750, rs1800629, rs1800896, rs1800872, rs1800795, rs1800470, and rs2430561 SNPs in relation with prognostic factors in acute myeloid leukemia. Cancer Med. 2019;8(12):5492-5506.IF=3.35 https://pubmed.ncbi.nlm.nih.gov/31373163/
  • Mártha K, Kerekes Máthé B, Moldovan VG, Bănescu C. Study of rs12532, rs8670 Polymorphism of Msh Homeobox 1 (MSX1), rs61754301, rs4904155 Polymorphism of Paired Box Gene 9 (PAX9), and rs2240308 Polymorphism of Axis Inhibitor Protein 2 (AXIN2) Genes in Nonsyndromic Hypodontia. Biomed Res Int. 2019 Nov 5;2019:2183720. doi: 10.1155/2019/2183720. eCollection 2019. IF=2.197 https://pubmed.ncbi.nlm.nih.gov/31781599/
  • Meliţ LE, Mărginean CO, Bănescu et al. The relationship between TLR4 rs4986790 and rs4986791 gene polymorphisms and Helicobacter pylori infection in children with gastritis.Pathol Res Pract. 2019;215(12):152692,doi:10.1016/j.prp.2019.152692; https://pubmed.ncbi.nlm.nih.gov/31690518/
  • Bănescu C. Do we really need genetic tests in current practice?. Rev Romana Med Lab. 2019;27(1):9-14. DOI:10.2478/rrlm-2019-0010, https://www.rrml.ro/articole/2019/2019_1_1.pdf
  • Bănescu C, Skrypnyk C. The Value of FLT3, NPM1 and DNMT3A Gene Mutation Analysis in Acute Myeloid Leukemia Diagnosis. Rev Romana Med Lab. 2019;27(3):239-43. DOI:10.2478/rrlm-2019-0024 , IF=0.8
  • Negovan A, Iancu M, Fülöp E, Bănescu C. Helicobacter pylori and cytokine gene variants as predictors of premalignant gastric lesions. World J Gastroenterol. 2019 Aug 14;25(30):4105-4124. doi: 10.3748/wjg.v25.i30.4105. (IF=3.411), https://www.rrml.ro/articole/2019/2019_3_1.pdf
  • Negovan A, Pantea M, Banescu C, Mocan S. Response to: Comment on „Factors Associated with Recurrent Ulcers in Patients with Gastric Surgery after More Than 15 Years: A Cross-Sectional Single-Center Study”. Gastroenterol Res Pract. 2019 Feb 24;2019:9214597. doi: 10.1155/2019/9214597. eCollection 2019. (IF=1.825), https://pubmed.ncbi.nlm.nih.gov/30918517/
  • Mărginean CO, Mărginean C, Iancu M, Moldovan VG, Melit LE, Bănescu C. The impact of TNF-α 308G>A gene polymorphism on children’s overweight risk and an assessment of biochemical variables: A cross-sectional single-center experience. Pediatr Neonatol. 2019 Feb;60(1):19-27. doi: 10.1016/j.pedneo.2018.03.003. (IF=1.497), https://pubmed.ncbi.nlm.nih.gov/29605384/
  • Mărginean C, Mărginean CO, Bănescu C, Meliţ LE, Tripon F, Iancu M. The relationship among GNB3 rs5443, PNPLA3 rs738409, GCKR rs780094 gene polymorphisms, type of maternal gestational weight gain and neonatal outcomes (STROBE-compliant article). Medicine (Baltimore). 2019 Jul;98(28):e16414. doi: 10.1097/MD.0000000000016414.(IF=1.870), https://pubmed.ncbi.nlm.nih.gov/31305457/
  • Crauciuc GA, Tripon F, Bogliş A, Făgărăşan A, Bănescu C. Multiplex ligation dependent probe amplification – A useful, fast and cost-effective method for identification of small supernumerary marker chromosome in children with developmental delay and congenital heart defect. Rev Romana Med Lab. 2018;26(4):461-70. DOI:10.2478/rrlm-2018-0032, IF=0.8, https://rrml.ro/articole/articol.php?year=2018&vol=4&poz=7
  • Bogliş A, Tripon F, Bănescu C. The utility of molecular genetic techniques in craniosynostosis cases associated with intellectual disability. Rev Romana Med Lab. 2018;26(4):471-7. DOI:10.2478/rrlm-2018-0033, ISSN 2284-5623, IF=0.8, https://reference-global.com/download/article/10.2478/rrlm-2018-0033.pdf
  • Negovan A, Iancu M, Tripon F, Crauciuc A, Mocan S, Bănescu C. The CAT-262 C>T, MnSOD Ala16Val, GPX1 Pro198Leu Polymorphisms Related to Oxidative Stress and the Presence of Gastric Lesions. J Gastrointestin Liver Dis; 2018:27(4):371-78. IF=2.063, https://pubmed.ncbi.nlm.nih.gov/30574618/
  • Trifa AP, Bănescu C, et al. Modest contribution of JAK2 V617F allele burden to the occurrence of major thrombosis in polycthemia vera and essential thrombocythemia. Blood Cells Mol Dis. 2018; 73:45-6. doi:10.1016/j.bcmd.2018.09.003.(IF=2.3) https://pubmed.ncbi.nlm.nih.gov/30249383/
  • MărgineanCO, Mărginean C, Bănescu C, et al. The relationship between MMP9 and ADRA2A gene polymorphisms and mothers–newborns’ nutritional status: an exploratory path model (STROBE compliant article). Pediatric Research. 2019;85(6):822-829. doi: 10.1038/s41390-019-0347-2 , https://pubmed.ncbi.nlm.nih.gov/30791043/
  • Tripon F, Crauciuc GA, Moldovan VG, Bogliș A, Benedek IJ, Lázár E, Bănescu C. Simultaneous FLT3, NPM1 and DNMT3A mutations in adult patients with acute myeloid leukemia – case study. Rev Romana Med Lab. 2019;27(3):245-54, https://rrml.ro/articole/articol.php?year=2019&vol=3&poz=2
  • Marginean C, Mărginean CO, Bănescu C, Melit LE, Tripon F, Iancu M. The relationship among GNB3 rs5443, PNPLA3 rs738409, GCKR rs780094 gene polymorphisms, type of maternal gestational weight gain and neonatal outcomes (STROBE-compliant article). Medicine. 2019; 98:28(e16414) DOI: 10.1097/MD.0000000000016414. https://pubmed.ncbi.nlm.nih.gov/31305457/
  • C Mărginean, CO Mărginean, M Iancu, LE Meliț, F Tripon, C Bănescu. MC4R and ENPP1 gene polymorphisms and their implication in maternal and neonatal risk for obesity. Scientific reports 2019; 9: https://www.nature.com/articles/s41598-019-47402-2
  • Negovan A, Iancu M, Mocan S, Banescu C. Immunohistochemistry as confirmatory test for current Helicobacter pylori infection in patients treated with proton pump inhibitors. Eur J Intern Med. 2018; 50:e31-e32. doi: 10.1016/j.ejim.2017.11.013. https://www.ncbi.nlm.nih.gov/pubmed/29203056
  • Mărginean CO, Mărginean C, Iancu M, … Bănescu C. The impact of TNF-α 308G>A gene polymorphism on children’s overweight risk and an assessment of biochemical variables: A cross-sectional single-center experience. Pediatr Neonatol. 2018. pii: S1875-9572(17)30211-5. doi: 10.1016/j.pedneo.2018.03.003. https://www.ncbi.nlm.nih.gov/pubmed/29605384
  • Trifa AP, Bănescu C, Bojan AS, et al. MECOM, HBS1L-MYB, THRB-RARB, JAK2, and TERT polymorphisms defining the genetic predisposition to myeloproliferative neoplasms: A study on 939 patients. Am J Hematol. 2018;93(1):100-106. doi: 10.1002/ajh.24946. https://pubmed.ncbi.nlm.nih.gov/29047144/
  • Muntean I, Şuteu C, Togănel R, Bănescu C. Association between MDR1 gene polymorphism and clinical course of pediatric pulmonary arterial hypertension. Rev Romana Med Lab. 2018;26(3):305-12,DOI:10.2478/rrlm-2018-0025https://www.rrml.ro/articole/articol.php?year=2018&vol=3&poz=5
  • Negovan A, Iancu M, Moldovan V, Sàrkàny K, Bataga S, Mocan S, Țilea I, Banescu C. The contribution of clinical and pathological predisposing factors to severe gastro-duodenal lesions in patients with long-term low-dose aspirin and proton pump inhibitor therapy. Eur J Intern Med. 2017 Oct;44:62-66. doi: 10.1016/j.ejim.2017.05.017. https://pubmed.ncbi.nlm.nih.gov/28576397/
  • Mărginean C, Bănescu CV, Mărginean CO, et al. Glutathione S-transferase (GSTM1, GSTT1) gene polymorphisms, maternal gestational weight gain, bioimpedance factors and their relationship with birth weight: a cross-sectional study in Romanian mothers and their newborns. Rom J Morphol Embryol. 2017;58(4):1285-1293., https://pubmed.ncbi.nlm.nih.gov/29556619/
  • Negovan A, Iancu M, Moldovan V, Mocan S, Banescu C. The Interaction between GSTT1, GSTM1, and GSTP1 Ile105Val Gene Polymorphisms and Environmental Risk Factors in Premalignant Gastric Lesions Risk. Biomed Res Int. 2017;2017:7365080. doi: 10.1155/2017/7365080. https://pubmed.ncbi.nlm.nih.gov/28182092/
  • Mărginean MO, Mărginean CO, Meliţ LE, Voidăzan S, Moldovan V, Bănescu C. The impact of host’s genetic susceptibility on Helicobacter pylori infection in children. Medicine (Baltimore). 2017; 96(30):e7612. doi: 10.1097/MD.0000000000007612. https://pubmed.ncbi.nlm.nih.gov/28746216/
  • Mărginean C, Mărginean CO, Iancu M, Meliţ LE, Tripon F, Bănescu C. The FTO rs9939609 and LEPR rs1137101 mothers-newborns gene polymorphisms and maternal fat mass index effects on anthropometric characteristics in newborns: A cross-sectional study on mothers-newborns gene polymorphisms-The FTO-LEPR Study (STROBE-compliant article). Medicine (Baltimore). 2016 Dec;95(49):e5551.(IF=2.133), https://pubmed.ncbi.nlm.nih.gov/27930556/
  • Georgescu AM, Bănescu C, Badea I, et al. IL-6 gene polymorphisms and sepsis in ICU adult Romanian patients: a prospective study. Rev Romana Med Lab.2017;25(1):75-89. DOI:10.1515/rrlm-2016-0044 https://www.rrml.ro/articole/2017/2017_1_7.pdf
  • Negovan A, Iancu M, Moldovan V, .., Banescu C. Clinical Risk Factors for Gastroduodenal Ulcer in Romanian Low-Dose Aspirin Consumers. Gastroenterol Res Pract. 2016;2016:7230626. doi: 10.1155/2016/7230626. (IF=1,742) https://www.hindawi.com/journals/grp/2016/7230626/abs/
  • Mărginean C, Mărginean CO, Iancu M, Szabo B, Cucerea M, Melit LE, Crauciuc A, Bănescu C. The role of TGF-β1 869 T > C and PPAR γ2 34 C > G polymorphisms, fat mass, and anthropometric characteristics in predicting childhood obesity at birth: A cross-sectional study according the parental characteristics and newborn’s risk for child obesity (the newborns obesity’s risk) NOR study. Medicine (Baltimore). 2016; 95(29):e4265. doi: 10.1097/MD.0000000000004265.(IF=2.133) https://pubmed.ncbi.nlm.nih.gov/27442659/
  • Mărginean C, Mărginean CO, Bănescu C, et al. Impact of demographic, genetic, and bioimpedance factors on gestational weight gain and birth weight in a Romanian population: A cross-sectional study in mothers and their newborns: the Monebo study (STROBE-compliant article). Medicine (Baltimore). 2016;95(27):e4098. doi: 10.1097/MD.0000000000004098.(IF=2.133) https://pubmed.ncbi.nlm.nih.gov/27399105/
  • Duicu C, Mărginean CO, Voidăzan S, Tripon F, Bănescu C. FTO rs 9939609 SNP Is Associated With Adiponectin and Leptin Levels and the Risk of Obesity in a Cohort of Romanian Children Population. Medicine (Baltimore). 2016 May;95(20):e3709. doi: 10.1097/MD.0000000000003709. (IF=2.133), https://pubmed.ncbi.nlm.nih.gov/27196486/
  • Bănescu V, Iancu M, Trifa AP, et al. From Six Gene Polymorphisms of the Antioxidant System, Only GPX Pro198Leu and GSTP1 Ile105Val Modulate the Risk of Acute Myeloid Leukemia. Oxid Med Cell Longev. 2016;2016:2536705. doi: 10.1155/2016/2536705. (IF= 4,492) http://www.hindawi.com/journals/omcl/2016/2536705/
  • Bănescu C, Iancu M, Trifa AP, et al. Influence of XPC, XPD, XPF, and XPG gene polymorphisms on the risk and the outcome of acute myeloid leukemia in a Romanian population. Tumour Biol. 2016 Jan 16. (IF=2,926) http://www.ncbi.nlm.nih.gov/pubmed/26779634
  • Mărginean CO, Mărginean C, Voidăzan S, Meliţ L, Crauciuc A, Duicu C, Bănescu C. Correlations Between Leptin Gene Polymorphisms 223 A/G, 1019 G/A, 492 G/C, 976 C/A, and Anthropometrical and Biochemical Parameters in Children With Obesity: A Prospective Case-Control Study in a Romanian Population-The Nutrichild Study. Medicine (Baltimore). 2016;95(12):e3115. doi: 10.1097/MD.0000000000003115. (IF=2.133) http://www.ncbi.nlm.nih.gov/pubmed/27015185
  • Mărginean A, Bănescu C, Moldovan V, Scridon A, et al. The Impact of CYP2C19 Loss-of-Function Polymorphisms, Clinical, and Demographic Variables on Platelet Response to Clopidogrel Evaluated Using Impedance Aggregometry. Clin Appl Thromb Hemost. 2016 pii: 1076029616629211. (IF=1.973) http://www.ncbi.nlm.nih.gov/pubmed/26873108
  • Negovan A, Iancu M, Moldovan V, et al. Influence of MDR1 C3435T, CYP2C19*2 and CYP2C19*3 gene polymorphisms and clinical characteristics on the severity of gastric lesions: a case-control study. J Gastrointestin Liver Dis, 2016, 25(2):2-4. (IF=1.891), http://www.jgld.ro/wp/archive/y2016/n2/a23/
  • Loghin A, Bănescu C, Nechifor-Boila A, et al. XRCC3 Thr241Met and XPD Lys751Gln gene polymorphisms and risk of clear cell renal cell carcinoma. Cancer Biomark. 2016 Feb 23;16(2):211-7. doi: 10.3233/CBM-150558. (IF=1.736) http://www.ncbi.nlm.nih.gov/pubmed/26682510
  • Aliment adjuvant în prevenția și/sau tratamentul bolii ficatului gras non-alcoolic, brevet nr. A/00412, din 11.07.2024
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